Crisaborole Impurity 11 CAS 943311-54-4
| CAS No. | 943311-54-4 |
| Molecular Formula | C14H10BNO3 |
| Molecular Weight | 251.05 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Crisaborole Impurity 11 (CAS 943311-54-4) is a certified pharmaceutical impurity reference standard with the molecular formula C14H10BNO3 and a molecular weight of 251.05 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Crisaborole Impurity 11 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 251.05 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Crisaborole Impurity 11 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H10BNO3 |
| Molecular Weight | 251.05 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole Hydrate Salt (CAS 2760304-92-3)
- Crisaborole Impurity 10 (CAS 906673-42-5)
- Crisaborole impurity 115 (CAS CATO-C4X-2021115)
- Crisaborole (CAS 906673-24-3)
- Crisaborole Impurity 9 (CAS 906673-30-1)
- Crisaborole Impurity 62 (CAS CATO-C4X-202162)
- Crisaborole-d4 (CAS CATO-C4X-202134)
- Crisaborole Impurity 35 (CAS CATO-C4X-202135)
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Why CATO?
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