(Z)-4-(3-(3,5-Dichlorophenyl)-4,4,4-trifluorobut-2-enoyl)-2-methylbenzamide CAS 943436-66-6
| CAS No. | 943436-66-6 |
| Molecular Formula | C18H12Cl2F3NO2 |
| Molecular Weight | 402.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), (Z)-4-(3-(3,5-Dichlorophenyl)-4,4,4-trifluorobut-2-enoyl)-2-methylbenzamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
(Z)-4-(3-(3,5-Dichlorophenyl)-4,4,4-trifluorobut-2-enoyl)-2-methylbenzamide (CAS 943436-66-6), molecular formula C18H12Cl2F3NO2 and molecular weight 402.19 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (Z)-4-(3-(3,5-Dichlorophenyl)-4,4,4-trifluorobut-2-enoyl)-2-methylbenzamide (C18H12Cl2F3NO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H12Cl2F3NO2 |
| Molecular Weight | 402.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Z Standards
- 1'-[(2E)-3-(3,4-dichlorophenyl)-2-propen-1-yl]-spiro[imidazolidine-4,3'-[3H]indole]-2,2',5(1'H)-trio (CAS 945736-61-8)
- (2Z)-1-(2,4-Dichlorophenyl)-3-(dimethylamino)-2-(4-fluorobenzenesulfonyl)prop-2-en-1-one (CAS 344265-59-4)
- 2-[5-(2,4-Dichlorophenyl)-1H-pyrazol-1-yl]-4-(4-methoxyphenyl)-1,3-thiazole (CAS 956977-62-1)
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- 1-(3,4-Dichlorophenyl)-3-({[(Z)-[1-(furan-2-yl)ethylidene]amino]carbamothioyl}amino)thiourea (CAS 866152-04-7)
- 2-{[(3,4-dichlorophenyl)methyl]sulfanyl}-1-methyl-1h-1,3-benzodiazole-5-sulfonamide (CAS 878620-41-8)
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- (5-((3,5-Dichlorophenyl)thio)-4-isopropyl-1-propyl-1H-imidazol-2-yl)methyl carbamate (CAS 178979-41-4)
Recommended Standards
- Ethyl 7-bromo-1-cyclopropyl-8-(difluoromethoxy)-1,4-dihydro-4-oxoquinoline-3-carboxylate (CAS 194805-07-7)
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- Platinum,dichloro(1-phenyl-1,2-ethanediamine-N,N')- (CAS 72426-83-6)
- N-(4-((3-Bromophenyl)amino)-6-nitroquinazolin-7-yl)acetamide (CAS 169205-91-8)
- Dimethyl 2-(2-phenylhydrazono)malonate (CAS 13732-26-8)
- 4-(8-Chloro-2,3-dihydro-1,4-benzodioxin-6-yl)-1h-pyrrole-3-carboxylic acid (CAS 1096815-60-9)
- (5-(4-Chloro-2-nitrophenyl)furan-2-yl)methanol (CAS 677025-05-7)
- 3-(Aminomethyl)-1-benzhydrylazetidine (CAS 36476-88-7)
- 4-(Difluoromethyl)bicyclo[2.2.2]Octane-1-carboxylic acid (CAS 1257397-59-3)
- Ketorolac-d5 (CAS 1215767-66-0)
- 5-(1-Methyl-1H-pyrazol-5-yl)-1,3,4-oxadiazol-2-amine (CAS 1204297-14-2)
- Sodium 2,2-difluorobutanoate (CAS 1346521-51-4)
- (S)-2-(tert-Butoxycarbonyl)-2-azaspiro[4.4]nonane-3-carboxylic acid (CAS 1608495-27-7)
- Cyclopeptide-5 (CAS 197172-76-2)
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