4-Chloro-2-fluoro-3-methylthiophenylboronic acid CAS 944128-91-0
| CAS No. | 944128-91-0 |
| Molecular Formula | C7H7BClFO2S |
| Molecular Weight | 220.46 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Chloro-2-fluoro-3-methylthiophenylboronic acid (CAS 944128-91-0), molecular formula C7H7BClFO2S and molecular weight 220.46 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-Chloro-2-fluoro-3-methylthiophenylboronic acid (C7H7BClFO2S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-Chloro-2-fluoro-3-methylthiophenylboronic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H7BClFO2S |
| Molecular Weight | 220.46 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 2-chloro-4-(methoxycarbonyl)phenyl boronic acid (CAS 603122-80-1)
- 2-Chloro-2-(2,3-dichlorophenyl)acetonitrile (CAS 1247048-13-0)
- 2-Chloro-2-(2,6-dichlorophenyl)acetonitrile (CAS 1247531-20-9)
- (2R)-1-chloro-3-iodo-propan-2-ol (CAS 2484878-87-5)
- (2S)-1-chloro-3-iodo-propan-2-ol (CAS 862113-07-3)
- 4-Chloro-5-(methoxycarbonyl)thiophene-2-boronic acid (CAS 2096331-56-3)
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Recommended Standards
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- 2-(3,4,5-Trichlorophenyl)acetonitrile (CAS 139256-46-5)
- 5-Bromonicotinoyl chloride (CAS 39620-02-5)
- 2-Amino-1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-phenylpropan-1-one hydrochloride (CAS 1236262-17-1)
- 2,5-Dibromoimidazo[2,1-b][1,3,4]thiadiazole (CAS 1206207-38-6)
- 1-Eicosanol (CAS 629-96-9)
- N,N-Dimethylbut-2-yne-1,4-diamine dihydrochloride (CAS 147555-80-4)
- 7-(Difluoromethyl)-2,2,3,3,6-pentafluoro-2,3-dihydrobenzo[b]thiophene (CAS 2413287-67-7)
- Ethyl 6-(2-ethoxy-2-oxoethyl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate (CAS 938189-69-6)
- 4-Methylheptanoic acid (CAS 3302-03-2)
- Benzyl (2-((S)-2-amino-N-methylpropanamido)cyclohexyl)carbamate (CAS 1354026-73-5)
- 4-Chloro-2-(difluoromethyl)-5-nitropyridine (CAS 1804755-81-4)
- Tirzepatide Impurity 12 (CAS CATO-C4X-324012)
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