4-Chloroquinazoline-2-carboxylic acid CAS 944902-14-1
| CAS No. | 944902-14-1 |
| Molecular Formula | C9H5ClN2O2 |
| Molecular Weight | 208.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 4-Chloroquinazoline-2-carboxylic acid (CAS 944902-14-1), a certified reference material (molecular formula C9H5ClN2O2, MW 208.60 g/mol) for analytical method development and quality control.
Structurally, 4-Chloroquinazoline-2-carboxylic acid (C9H5ClN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 208.60 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H5ClN2O2 |
| Molecular Weight | 208.60 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloroquinazoline Standards
- 4-Chloroquinazoline-8-carboxylic acid (CAS 1824465-41-9)
- 2-Chloroquinazoline-4-carboxylic acid (CAS 944902-11-8)
- 5-Chloroquinazoline-2,4,6-triamine (CAS 17511-20-5)
- 5-Chloroquinazoline-2,4(1H,3H)-dione (CAS 78754-81-1)
- 4-chloroquinazoline-5-carbonitrile (CAS 1231761-53-7)
- 4-chloroquinazoline-6-carbonitrile (CAS 150449-97-1)
- 6-chloroquinazoline-2-carboxylic acid (CAS 1204390-45-3)
- 2-chloroquinazoline-7-carboxylic acid (CAS 1429422-30-9)
Recommended Standards
- 4-Chlorophthalazine-6-carboxylic acid (CAS 2168331-87-9)
- 4-Oxo-4h-chromene-2-carbonyl chloride (CAS 5112-47-0)
- 4-Chloro-8-nitroquinoline (CAS 23833-99-0)
- 5-(3-Chlorophenyl)-1,3,4-oxadiazole-2-carbaldehyde (CAS 944907-07-7)
- 3-{4-[(2-chloro-6-fluorophenyl)methoxy]phenyl}-1-(4-methylbenzenesulfonyl)-1H-pyrazole (CAS 477710-94-4)
- methyl 2-(2-bromo-4,5-difluorophenyl)acetate (CAS 1807187-56-9)
- 1,3-Dimorpholinopropane-1,3-dione (CAS 10256-01-6)
- Metoclopramide EP Impurity B (CAS 4093-31-6)
- 2-[4-(trideuteriomethoxymethyl)norbornan-1-yl]ethanol (CAS 2725774-30-9)
- 3-Fluoro-4-nitrobenzimidamide (CAS 1260813-64-6)
- Rimegepant Impurity 118 (CAS CATO-C4X-2487118)
- 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-3-(1-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-indol-3-yl}ethenyl)-1H-indole (CAS 338393-40-1)
- (1-(3,5-Difluorophenyl)-3-isopropyl-1h-indol-2-yl)methanol (CAS 886362-94-3)
- Des-Ala21-Tirzepatide (CAS CATO-CPTD788952)
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