5-Chloro-2-(chloromethyl)pyrimidine CAS 944902-28-7
| CAS No. | 944902-28-7 |
| Molecular Formula | C5H4Cl2N2 |
| Molecular Weight | 163.00 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-Chloro-2-(chloromethyl)pyrimidine (CAS 944902-28-7), molecular formula C5H4Cl2N2 and molecular weight 163.00 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-Chloro-2-(chloromethyl)pyrimidine (C5H4Cl2N2) is characterized by a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Chloro-2-(chloromethyl)pyrimidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H4Cl2N2 |
| Molecular Weight | 163.00 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 3-Chloro-6-chloromethylpyridazine (CAS 120276-59-7)
- 2-Chloro-4-(chloromethyl)pyrimidine (CAS 944902-31-2)
- 4-Chloro-2-(chloromethyl)pyrimidine (CAS 3842-28-2)
- 4-chloro-6-(chloromethyl)pyrimidine (CAS 85878-84-8)
- chloro(chloromethanesulfonyl)methane (CAS 37557-97-4)
- 1-Chloro-2-methyloctane (CAS 121246-22-8)
- 1-Chloro-6,6-dimethylheptane (CAS 1339880-47-5)
- 1-Chloro-2,2,5-trimethylhexane (CAS 1489352-82-0)
Recommended Standards
- 5-Amino-2,4-dichloropyridine (CAS 7321-93-9)
- 3,5-Dichloro-4-AMino Pyridine (CAS 228809-78-7)
- 5-Amino-2,3-dichloropyridine (CAS 98121-41-6)
- 2,6-Dichloropyridin-4-amine (CAS 2587-02-2)
- 5-Acetyl-d3-amino-6-formylamino-3-methyluracil (CAS 1185082-65-8)
- 1-((3-(Trifluoromethyl)phenoxy)methyl)-1h-pyrazole-3-carbohydrazide (CAS 1004193-88-7)
- 4-Amino-N-(3-(2-hydroxyethyl)sulfonylphenyl)benzamide (CAS 20241-68-3)
- 1-Azido-3-chlorobenzene (CAS 3296-06-8)
- 1-Phenyl-2-(piperazin-1-yl)ethan-1-one dihydrochloride (CAS 109608-71-1)
- Avanafil Impurity 78 (CAS 56633-75-1)
- 1-((4-Chlorophenyl)sulfonyl)-1,4-diazepan-5-one (CAS 385400-72-6)
- 6-Hydroxy-1,1,3,3-tetramethyl-2,3-dihydro-1H-indene-5-carbaldehyde (CAS 93777-71-0)
- 1-(7-(4-Hydroxy-3-methoxyphenyl)-5-methyl-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)ethan-1-one (CAS 380466-92-2)
- Liraglutide(10-22)TFA Salt (CAS CATO-C4X-199211)
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