6-Chloro-N-(2-methoxybenzyl)pyrimidin-4-amine CAS 945896-53-7
| CAS No. | 945896-53-7 |
| Molecular Formula | C12H12ClN3O |
| Molecular Weight | 249.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
6-Chloro-N-(2-methoxybenzyl)pyrimidin-4-amine (CAS 945896-53-7) is a high-purity analytical reference standard with the molecular formula C12H12ClN3O and a molecular weight of 249.70 g/mol.
The molecular framework of 6-Chloro-N-(2-methoxybenzyl)pyrimidin-4-amine (C12H12ClN3O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C12H12ClN3O |
| Molecular Weight | 249.70 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 4-Chloro-6-(3,4-dimethylphenoxy)pyrimidin-2-amine (CAS 100763-74-4)
- 2-Chloro-1-(3,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-1(2H)-yl)ethan-1-one (CAS 1030459-12-1)
- 6-Chloro-N-(2-methoxybenzyl)pyridazin-3-amine (CAS 1036518-29-2)
- N-(5-Chloro-2-formyl-1H-indol-3-yl)-N,N-dimethylimidoformamide (CAS 1142214-23-0)
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- 2-chloro-N-[4-(1H-imidazol-4-yl)phenyl]propanamide (CAS 1153508-34-9)
- 2-chloro-n-[(4-methoxyphenyl)methyl]pyrimidin-4-amine (CAS 115581-31-2)
- 6-Chloro-N-(3-methoxybenzyl)pyridazin-3-amine (CAS 1184826-33-2)
Recommended Standards
- 6-(Chloromethyl)-N2-methyl-N2-phenyl-1,3,5-triazine-2,4-diamine (CAS 696621-14-4)
- 6-Chloro-N-(3-methoxybenzyl)pyrimidin-4-amine (CAS 945896-67-3)
- 6-(chloromethyl)-N2-(o-tolyl)-1,3,5-triazine-2,4-diamine (CAS 568570-13-8)
- 6-Chloro-N-(4-methoxybenzyl)pyrazin-2-amine (CAS 355836-31-6)
- alpha-cis-Bergamotene (CAS 18252-46-5)
- 3'-methoxy-3-(4-thiomethylphenyl)propiophenone (CAS 898780-83-1)
- 3-(difluoromethyl)triazole-4-carbaldehyde (CAS 2845318-70-7)
- 3-(3,4-Dimethoxybenzenesulfonyl)propanoic acid (CAS 100059-84-5)
- (3-Methoxyphenyl)hydrazine Hydrochloride (CAS 39232-91-2)
- 4-(Naphthalen-2-yl)butan-2-one (CAS 68427-26-9)
- N-Nitroso Buspirone EP Impurity A (CAS 872826-80-7)
- 1-(1,5-Dimethyl-1H-pyrazol-3-yl)-2,2,2-trifluoroethan-1-ol (CAS 2228136-05-6)
- Methyl 3-(N-(p-tolyl)sulfamoyl)benzo[b]thiophene-2-carboxylate (CAS 899977-35-6)
- Des-Ala18-Tirzepatide (CAS CATO-CPTD788955)
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