2-(Fluoromethyl)-4-[(trimethylsilyl)ethynyl]thiazole CAS 945933-40-4

Purity 97%+In StockPharmaceutical Standards
CAS No.945933-40-4
Molecular FormulaC9H12FNSSi
Molecular Weight213.35 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

2-(Fluoromethyl)-4-[(trimethylsilyl)ethynyl]thiazole CAS 945933-40-4 chemical structure

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(Fluoromethyl)-4-[(trimethylsilyl)ethynyl]thiazole.

CATO supplies 2-(Fluoromethyl)-4-[(trimethylsilyl)ethynyl]thiazole (CAS 945933-40-4), a certified reference material (molecular formula C9H12FNSSi, MW 213.35 g/mol) for analytical method development and quality control.

The molecular framework of 2-(Fluoromethyl)-4-[(trimethylsilyl)ethynyl]thiazole (C9H12FNSSi) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC9H12FNSSi
Molecular Weight213.35 g/mol
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, acetonitrile, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)4.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1987
Halogen ContentF-containing
Nitrogen Atoms1
Sulfur Atoms1

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