4-(2-Methoxyphenoxy)-3-(trifluoromethyl)aniline CAS 946775-72-0
| CAS No. | 946775-72-0 |
| Molecular Formula | C14H12F3NO2 |
| Molecular Weight | 283.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(2-Methoxyphenoxy)-3-(trifluoromethyl)aniline.
4-(2-Methoxyphenoxy)-3-(trifluoromethyl)aniline (CAS 946775-72-0), molecular formula C14H12F3NO2 and molecular weight 283.25 g/mol, is a CATO reference standard with documented purity and traceability.
4-(2-Methoxyphenoxy)-3-(trifluoromethyl)aniline (C14H12F3NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-(2-Methoxyphenoxy)-3-(trifluoromethyl)aniline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H12F3NO2 |
| Molecular Weight | 283.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Methoxyphenoxy Standards
- 2-(2-Methoxyphenoxy)-5-(trifluoromethyl)aniline (CAS 175135-08-7)
- 2-(3-Methoxyphenoxy)-5-(trifluoromethyl)aniline (CAS 728907-96-8)
- 2-(4-Methoxyphenoxy)-5-(trifluoromethyl)aniline (CAS 62966-74-9)
- 4-(2-Methoxyphenoxy)-2-(trifluoromethyl)aniline (CAS 946741-20-4)
- 4-(3-Methoxyphenoxy)-2-(trifluoromethyl)aniline (CAS 946784-63-0)
- 4-(3-Methoxyphenoxy)-3-(trifluoromethyl)aniline (CAS 946662-85-7)
- 4-(4-Methoxyphenoxy)-2-(trifluoromethyl)aniline (CAS 946663-25-8)
- 4-(4-Methoxyphenoxy)-3-(trifluoromethyl)aniline (CAS 87294-18-6)
Recommended Standards
- 4-(3-(Trifluoromethyl)quinoxalin-2-yl)morpholine (CAS 337920-42-0)
- 4-(2-(Trifluoromethyl)quinazolin-4-yl)morpholine (CAS 914219-13-9)
- 4-(1-(3-(Trifluoromethyl)phenoxy)ethyl)pyrimidin-2-amine (CAS 338976-09-3)
- 4-(((2,6-Dimethylphenyl)imino)methyl)-5-(trifluoromethyl)-1,2-dihydro-3H-pyrazol-3-one (CAS 339107-16-3)
- 6-Bromo-3-(bromomethyl)-2-methoxypyridine (CAS 1805208-46-1)
- N-(5-Methylpyrazin-2-yl)acetamide (CAS 5521-59-5)
- 4-(((1H-1,2,4-Triazol-1-yl)imino)methyl)benzene-1,2-diol (CAS 324033-15-0)
- 5-(Aminomethyl)-N-methyl-1,2,4-oxadiazole-3-carboxamide (CAS 1209584-76-8)
- 2-{[(2-chlorophenyl)carbamoyl]amino}-4,6-dimethylpyridine-3-carboxamide (CAS 338975-92-1)
- 4-(Difluoromethyl)-5-hydroxy-6-methylpyridine-2-sulfonamide (CAS 1807122-99-1)
- 1-Bromo-3-(pentyloxy)benzene (CAS 157245-77-7)
- 5,5-Dimethylhydantoin (CAS 77-71-4)
- 5-[(2-amino-2-methyl-propyl)-methyl-amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione (CAS 2703768-63-0)
- (Des-Bromo)-Neuropeptide B (1-23) (human) (CAS 434897-64-0)
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