B-Raf IN 1, 98%, a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM CAS 950736-05-7

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including B-Raf IN 1, 98%, a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM.

B-Raf IN 1, 98%, a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM (CAS 950736-05-7) is a high-purity analytical reference standard with the molecular formula C29H24F3N5O and a molecular weight of 515.53 g/mol.

Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, B-Raf IN 1, 98%, a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 515.53 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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