2-Fluoro-3-hydroxybenzamide CAS 951122-84-2
| CAS No. | 951122-84-2 |
| Molecular Formula | C7H6FNO2 |
| Molecular Weight | 155.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-Fluoro-3-hydroxybenzamide (CAS 951122-84-2) is a high-purity analytical reference standard with the molecular formula C7H6FNO2 and a molecular weight of 155.13 g/mol.
The molecular framework of 2-Fluoro-3-hydroxybenzamide (C7H6FNO2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H6FNO2 |
| Molecular Weight | 155.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluoro Standards
- 2-(6-Fluoro-2-pyridyl)acetic Acid (CAS 1000517-25-8)
- 5-Fluoro-6-methylpyridine-2-carboxylic Acid (CAS 1005474-88-3)
- 2-Fluoro-5-methylnicotinic acid (CAS 1042986-00-4)
- 6-Fluoro-4-methylpicolinic acid (CAS 1060804-75-2)
- 2-Fluoro-4-methylpyridine-3-carboxylic acid (CAS 1060804-77-4)
- 4-Fluoro-6-methylpicolinic acid (CAS 1060805-99-3)
- 2-Fluoro-6-methylisonicotinic acid (CAS 1060806-00-9)
- 4-Fluoro-6-methylnicotinic acid (CAS 1060806-01-0)
Recommended Standards
- 2-Amino-6-fluoronicotinamide (CAS 86724-80-3)
- 2-Fluoro-3-methylpyridine-4-carboxylic acid (CAS 885589-17-3)
- 2-Amino-6-fluorobenzoic Acid (CAS 434-76-4)
- 2-Fluoro-3-nitrotoluene (CAS 437-86-5)
- ethyl 2-(oxan-4-yl)-2-oxoacetate (CAS 861160-58-9)
- N-(2-methoxyethyl)-2-nitro-4-(trifluoromethyl)aniline (CAS 161605-63-6)
- ({4-[(2-naphthylsulfonyl)amino]benzoyl}amino)acetic acid (CAS 796083-82-4)
- 2-Chloro-N-ethyl-N-phenylbenzamide (CAS 95415-53-5)
- Ethyl 1-amino-1H-imidazole-2-carboxylate (CAS 1008130-15-1)
- (4-Acetamidophenyl)(fluorosulfonyl)sulfamoyl fluoride (CAS 2172794-56-6)
- 2-((Trimethylsilyl)ethynyl)thiazole (CAS 113705-15-0)
- n,2,4,5-Tetramethylbenzenesulfonamide (CAS 889779-88-8)
- 3-Methylbut-3-en-1-yl methanesulfonate (CAS 80352-66-5)
- Tirzepatide Impurity 46 (CAS CATO-C4X-324046)
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