5-Chloro-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxylic acid CAS 953729-63-0
| CAS No. | 953729-63-0 |
| Molecular Formula | C8H5ClF3NO3 |
| Molecular Weight | 255.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-Chloro-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxylic acid is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 5-Chloro-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxylic acid (CAS 953729-63-0), a certified reference material (molecular formula C8H5ClF3NO3, MW 255.58 g/mol) for analytical method development and quality control.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 5-Chloro-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxylic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 255.58 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 5-Chloro-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxylic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H5ClF3NO3 |
| Molecular Weight | 255.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 3-chloro-6-(2,2,2-trifluoroethoxy)pyridine-2-carboxylic acid (CAS 1021043-31-1)
- 3-Chloro-2-methoxy-5-(trifluoromethyl)isonicotinic acid (CAS 1221792-35-3)
- 1-(5-Chloro-2-nitrophenyl)-2,2,2-trifluoroethan-1-ol (CAS 1384243-41-7)
- 1-(4-Chloro-3-nitrophenyl)-2,2,2-trifluoroethan-1-ol (CAS 1554108-97-2)
- 4-Chloro-2-(methoxycarbonyl)-6-(trifluoromethyl)pyridine 1-oxide (CAS 1956356-35-6)
- 3-CHLORO-2-(METHOXYCARBONYL)-5-(TRIFLUOROMETHYL)PYRIDINE 1-OXIDE (CAS 1958091-84-3)
- (5-Chloro-2-nitro-4-(trifluoromethyl)phenyl)hydrazine (CAS 306935-07-9)
- 1-(4-Chloro-2-nitrophenyl)-2,2,2-trifluoroethanol (CAS 2228945-51-3)
Recommended Standards
- 4-Chloro-2-methoxy-6-(trifluoromethyl)nicotinic acid (CAS 916160-42-4)
- 6-Chloro-5-(2,2,2-trifluoroethoxy)picolinic acid (CAS 855916-43-7)
- 2-Amino-3-chloro-5-(trifluoromethoxy)benzoic acid (CAS 433938-46-6)
- N-(5-Chloro-2-fluoro-4-(trifluoromethyl)phenyl)acetamide (CAS 114973-36-3)
- N-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)-3-methoxybenzamide (CAS 477885-73-7)
- Cevimeline Sulfoxide (CAS 124751-36-6)
- 2-(Imidazo[2,1-b]thiazol-6-yl)-N-(4h-1,2,4-triazol-3-yl)acetamide (CAS 1050837-99-4)
- 1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-amine (CAS 1200606-31-0)
- 6-Fluoro-1H-indol-2-amine hydrochloride (CAS 1262587-80-3)
- 2-Fluoro-4-hydroxybenzoic Acid (CAS 65145-13-3)
- Ethyl 2-acetyloctanoate (CAS 29214-60-6)
- 2-Methyloxazolo[5,4-c]pyridine (CAS 83431-05-4)
- (3R,4S)-4-(4-Fluorophenyl)pyrrolidine-3-carboxylic acid (CAS 1260587-88-9)
- Semaglutide impurity 208 (CAS CATO-C4X-2226208)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
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