6-Cyclopropyl-3-phenyl-[1,2]oxazolo[5,4-b]pyridine-4-carboxylic acid CAS 953733-48-7
| CAS No. | 953733-48-7 |
| Molecular Formula | C16H12N2O3 |
| Molecular Weight | 280.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 6-Cyclopropyl-3-phenyl-[1,2]oxazolo[5,4-b]pyridine-4-carboxylic acid is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 6-Cyclopropyl-3-phenyl-[1,2]oxazolo[5,4-b]pyridine-4-carboxylic acid (CAS 953733-48-7), a certified reference material (molecular formula C16H12N2O3, MW 280.28 g/mol) for analytical method development and quality control.
The molecular framework of 6-Cyclopropyl-3-phenyl-[1,2]oxazolo[5,4-b]pyridine-4-carboxylic acid (C16H12N2O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H12N2O3 |
| Molecular Weight | 280.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 2 |
Related Cyclopropyl Standards
- 1-cyclopropyl-5-(2-hydroxybenzoyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile (CAS 879304-27-5)
- 3-Cyclopropyl-6-phenyl-[1,2]oxazolo[5,4-b]pyridine-4-carboxylic acid (CAS 954578-92-8)
- trans-1-cyclopropyl-2-(3,4-difluorophenyl)-5-oxopyrrolidine-3-carboxamide (CAS 1820579-97-2)
- 4-Cyclopropyl-2-(ethylsulfonyl)-6-(trifluoromethyl)pyrimidine (CAS 832737-29-8)
- 2-[4-cyclopropyl-2,5-dioxo-4-(thiophen-2-yl)imidazolidin-1-yl]acetic acid (CAS 1270850-79-7)
- 4-Cyclopropyl-1-(2,4-dimethylphenyl)-1,6-dihydro-7H-pyrazolo[3,4-d]pyridazin-7-one (CAS 1105197-25-8)
- 4-Cyclopropyl-1-(3,4-dimethylphenyl)-1,6-dihydro-7H-pyrazolo[3,4-d]pyridazin-7-one (CAS 1105197-29-2)
- 2-((1-Cyclopropyl-1h-tetrazol-5-yl)thio)-1-(5-methylthiophen-2-yl)ethan-1-one (CAS 1030222-96-8)
Recommended Standards
- 6-Benzyl-4-oxo-1,4-dihydrocinnoline-3-carboxylic acid (CAS 36991-60-3)
- 6-Hydroxy-2-(4-hydroxyphenyl)-3-phenylpyrimidin-4(3H)-one (CAS 65249-17-4)
- 6-amino-1-(4-methoxyphenyl)-3-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile (CAS 948301-94-8)
- 6-Methoxy-4-methyl-2-phenylquinazoline-5,8-dione (CAS 61416-94-2)
- Tetrakis(acetonitrile)palladium(II) Bis(trifluoromethanesulfonate) (CAS 68569-14-2)
- n-[3-(2-chloroacetyl)-2,5-dimethyl-1h-pyrrol-1-yl]benzamide (CAS 781626-59-3)
- Methyl 1H-pyrazole-5-carboxylate (CAS 394658-31-2)
- 5-bromo-1H-pyrrolo[2,3-b]pyridine-3-sulfonyl chloride (CAS 1801906-01-3)
- Methyl 3-(tert-butyl)-5-chlorobenzoate (CAS 1000341-35-4)
- Fmoc-β-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-Ala-OH (CAS 252049-13-1)
- 3-Cyclopropylpyrazole-4-carboxylic Acid (CAS 870704-26-0)
- 3-Hydroxy-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane (CAS 5947-36-4)
- Guanfacine Hydrochloride (CAS 29110-48-3)
- Semaglutide impurity 30 (CAS CATO-C4X-222630)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com