4-(Chloromethyl)-2-(3-fluorophenyl)thiazole CAS 953736-97-5
| CAS No. | 953736-97-5 |
| Molecular Formula | C10H7ClFNS |
| Molecular Weight | 227.69 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-(Chloromethyl)-2-(3-fluorophenyl)thiazole (C10H7ClFNS) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies 4-(Chloromethyl)-2-(3-fluorophenyl)thiazole (CAS 953736-97-5), a certified reference material (molecular formula C10H7ClFNS, MW 227.69 g/mol) for analytical method development and quality control.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H7ClFNS |
| Molecular Weight | 227.69 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Chloromethyl Standards
- 4-(Chloromethyl)-2-(4-fluorophenyl)thiazole (CAS 113264-13-4)
- 5-(Chloromethyl)-2-(4-fluorophenyl)thiazole (CAS 1206973-54-7)
- 4-(chloromethyl)-2-(2-fluorophenyl)-1,3-thiazole (CAS 138128-84-4)
- 5-(Chloromethyl)-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine (CAS 14142-90-6)
- 2-(Chloromethyl)-4-(4-fluorophenyl)thiazole (CAS 170881-68-2)
- 4-(Chloromethyl)-6-(1-piperidinyl)-1,3,5-triazin-2-amine (CAS 90797-31-2)
- 5-(Chloromethyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)pyridine (CAS 906352-80-5)
- 6-(chloromethyl)phenanthridine (CAS 40484-36-4)
Recommended Standards
- 4-(6-Chloropyrimidin-4-yl)-2,6-dimethylmorpholine (CAS 945897-03-0)
- 4-(4-Chloropyrimidin-2-yl)-2,6-dimethylmorpholine (CAS 944900-43-0)
- 4-{[(2-chlorophenyl)methyl]amino}butanoic acid (CAS 926191-52-8)
- 4-(4-Chloro-6-ethylpyrimidin-2-yl)morpholine (CAS 901586-60-5)
- 6-Mercapto-4-methylnicotinonitrile (CAS 1355196-94-9)
- Flucloxacillin RC 3 (CAS 1796928-46-5)
- 1,4-dioxane-2-carbohydrazide (CAS 1097812-58-2)
- (3R)-3-(nitromethyl)-3H-2-benzofuran-1-one (3R)-3-(nitromethyl)-3H-isobenzofuran-1-one 3598-68-3 A823078 (CAS 3598-68-3)
- 3-(4,5,6,7-Tetrahydro-1h-indazol-1-yl)propanoic acid (CAS 889940-07-2)
- N2-Cyclopentyl-N4-ethyl-6-(methylthio)-1,3,5-triazine-2,4-diamine (CAS 84712-78-7)
- 2-(3-Chlorophenyl)-8-methylimidazo[1,2-a]pyridine-3-carbaldehyde (CAS 898380-05-7)
- 5-Bromo-1H-indol-7-amine (CAS 374537-99-2)
- Methyl 6-bromo-5-(trifluoromethyl)picolinate (CAS 1256787-29-7)
- Semaglutide Impurity 131 (CAS 2618647-80-4)
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