1-(difluoromethyl)-4-nitro-1H-pyrazole CAS 956477-64-8

Purity 97%+In StockPharmaceutical Standards
CAS No.956477-64-8
Molecular FormulaC4H3F2N3O2
Molecular Weight163.08 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

1-(difluoromethyl)-4-nitro-1H-pyrazole CAS 956477-64-8 chemical structure

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(difluoromethyl)-4-nitro-1H-pyrazole.

1-(difluoromethyl)-4-nitro-1H-pyrazole (CAS 956477-64-8), molecular formula C4H3F2N3O2 and molecular weight 163.08 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 1-(difluoromethyl)-4-nitro-1H-pyrazole (C4H3F2N3O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 1-(difluoromethyl)-4-nitro-1H-pyrazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC4H3F2N3O2
Molecular Weight163.08 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)4.0
UV AbsorptionUV-absorbing
CAS Registry Year (est.)1987
Halogen ContentF-containing
Nitrogen Atoms3

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Why CATO?