4-(4-Bromo-1H-pyrazol-1-yl)-6-chloropyrimidine CAS 957035-29-9
| CAS No. | 957035-29-9 |
| Molecular Formula | C7H4BrClN4 |
| Molecular Weight | 259.49 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(4-Bromo-1H-pyrazol-1-yl)-6-chloropyrimidine.
4-(4-Bromo-1H-pyrazol-1-yl)-6-chloropyrimidine (CAS 957035-29-9) is a high-purity analytical reference standard with the molecular formula C7H4BrClN4 and a molecular weight of 259.49 g/mol.
Owing to a nitrile group, chlorine/bromine substitution, an aromatic ring system, 4-(4-Bromo-1H-pyrazol-1-yl)-6-chloropyrimidine is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 259.49 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-(4-Bromo-1H-pyrazol-1-yl)-6-chloropyrimidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H4BrClN4 |
| Molecular Weight | 259.49 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 4 |
Related Bromo Standards
- 4-Bromo-7-chloro-1H-pyrrolo[3,2-c]pyridine-3-carbaldehyde (CAS 1000341-99-0)
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- 7-Bromo-4-chlorophthalazin-1(2H)-one (CAS 1028338-57-9)
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Recommended Standards
- 3-Bromo-7-chloro-1,6-naphthyridin-2(1H)-one (CAS 2761070-91-9)
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- 4-Bromo-6-chloro-2,7-naphthyridin-1(2H)-one (CAS 2375601-52-6)
- N,N-Dimethyl-1-(o-tolyl)-1H-pyrazol-4-amine (CAS 801170-65-0)
- n-(4-Bromo-3-fluorobenzyl)-2-methylpropan-1-amine (CAS 1249704-82-2)
- 3-Cyclopropoxy-2-isopropylbenzonitrile (CAS 1243450-57-8)
- 2-Methyldecahydroisoquinoline (CAS 23994-18-5)
- 4-Fluoro-1-methoxy-2-nitrobenzene (CAS 445-83-0)
- Cyclopropanecarboximidamide (CAS 54070-74-5)
- 2,6-Diisopropylpyrazine (CAS 222048-85-3)
- Cabazitaxel Impurity 34 (CAS CATO-C4X-111534)
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