1-Bromo-2-(4-fluorophenyl)acetylene CAS 95895-33-3
| CAS No. | 95895-33-3 |
| Molecular Formula | C8H4BrF |
| Molecular Weight | 199.02 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-Bromo-2-(4-fluorophenyl)acetylene (CAS 95895-33-3) is a high-purity analytical reference standard with the molecular formula C8H4BrF and a molecular weight of 199.02 g/mol.
1-Bromo-2-(4-fluorophenyl)acetylene (C8H4BrF) contains fluorine/bromine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4BrF |
| Molecular Weight | 199.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F/Br-containing |
Related Bromo Standards
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Recommended Standards
- (R)-Isopropyl 2-bromo-2-fluoroacetate (CAS 2209873-84-5)
- 2-Bromo-4-ethynyl-1-fluorobenzene (CAS 918487-39-5)
- 4-Bromo-1-ethynyl-2-fluorobenzene (CAS 302912-33-0)
- 4-Bromo-2-ethynyl-1-fluorobenzene (CAS 657427-46-8)
- tert-Butyl (2-(furan-3-yl)-2-oxoethyl)carbamate (CAS 832077-46-0)
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- 5-Chlorothiophene-2,4-dicarbaldehyde (CAS 65762-93-8)
- 2-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}-4-phenylpyridine-3-carbonitrile (CAS 860650-51-7)
- (3-Amino-4-chlorophenyl)(p-tolyl)methanone (CAS 106841-04-7)
- 1,2,4,5-Tetrakis(diphenylphosphaneyl)benzene (CAS 123739-99-1)
- Methyl 4-(aminomethyl)-5-methylfuran-2-carboxylate hydrochloride (CAS 35842-91-2)
- 2,3,5-Trifluoro-4-iodopyridine (CAS 1057393-65-3)
- Endo-Gly29-Tirzepatide (CAS CATO-CPTD788685)
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