3-Amino-5-chlorobenzenesulfonic acid CAS 98-21-5
| CAS No. | 98-21-5 |
| Molecular Formula | C6H6ClNO3S |
| Molecular Weight | 207.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Amino-5-chlorobenzenesulfonic acid.
3-Amino-5-chlorobenzenesulfonic acid (CAS 98-21-5) is a high-purity analytical reference standard with the molecular formula C6H6ClNO3S and a molecular weight of 207.63 g/mol.
The molecular framework of 3-Amino-5-chlorobenzenesulfonic acid (C6H6ClNO3S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 3-Amino-5-chlorobenzenesulfonic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H6ClNO3S |
| Molecular Weight | 207.63 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Amino Standards
- 3-Amino-4-chlorobenzenesulfonic acid (CAS 98-36-2)
- 4-Amino-3-chlorobenzenesulfonic acid (CAS 98-35-1)
- 6-Amino-5-chloropyridine-3-sulfonamide (CAS 1269152-45-5)
- 4-Amino-5-chloropyridine-3-sulfonamide (CAS 1352496-64-0)
- 2-Amino-5-chloropyridine-3-sulfonamide (CAS 163137-44-8)
- (s)-2-Amino-2-(2-chloro-3,6-difluorophenyl)ethan-1-ol (CAS 1212946-05-8)
- (r)-2-Amino-2-(4-chloro-2,5-difluorophenyl)ethan-1-ol (CAS 1212955-77-5)
- (r)-2-Amino-2-(3-chloro-2,4-difluorophenyl)ethan-1-ol (CAS 1213080-88-6)
Recommended Standards
- 3-Chloro-2-(2-fluorophenyl)pyridine (CAS 387827-67-0)
- 2-Methoxy-3-pyridinesulfonyl Chloride (CAS 219715-44-3)
- 3-Chloro-2-(4-fluorophenyl)pyridine (CAS 847226-00-0)
- 2-chloro-5-hydroxybenzene-1-sulfonamide (CAS 86093-06-3)
- 2,3-Dihydroxypropyl 3-oxobutanoate (CAS 66523-11-3)
- 2-((tert-Butoxycarbonyl)amino)-2-(pyridin-4-yl)acetic acid (CAS 369403-56-5)
- 4-(Methylsulfonyl)-1,1'-biphenyl (CAS 6462-34-6)
- 2-Bromo-5-bromomethyl-thiazole (CAS 131748-91-9)
- 4-Hydroxy-2,6-bis(perfluorophenyl)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine 4-oxide (CAS 1836233-60-3)
- Troglitazone Sulfate Ammonium Salt (CAS 107187-86-0)
- (1R,2R)-2-((tert-butoxycarbonyl)amino)-1-fluorocyclobutane-1-carboxylic acid (CAS 1639454-84-4)
- 5,7-Diaminoquinoline-8-thiol (CAS 653570-17-3)
- Dexmedetomidine Impurity 97 (CAS CATO-C4X-123097)
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