2,4,5-Trifluorobenzamide CAS 98349-23-6
| CAS No. | 98349-23-6 |
| Molecular Formula | C7H4F3NO |
| Molecular Weight | 175.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2,4,5-Trifluorobenzamide.
2,4,5-Trifluorobenzamide (CAS 98349-23-6) is a high-purity analytical reference standard with the molecular formula C7H4F3NO and a molecular weight of 175.11 g/mol.
The molecular framework of 2,4,5-Trifluorobenzamide (C7H4F3NO) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2,4,5-Trifluorobenzamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H4F3NO |
| Molecular Weight | 175.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluorobenzamide Standards
- 2,3,5-Trifluorobenzamide (CAS 238403-46-8)
- 2,3,6-Trifluorobenzamide (CAS 207986-22-9)
- 2,4,6-Trifluorobenzamide (CAS 82019-50-9)
- 2,3,4-trifluorobenzamide 2,3,4-tris(fluoranyl)benzamide 207919-09-3 A814905 (CAS 207919-09-3)
- 3,4,5-trifluorobenzamide 3,4,5-tris(fluoranyl)benzamide 78324-75-1 A839393 (CAS 78324-75-1)
Recommended Standards
- 4-(trifluoromethyl)pyridine-3-carbaldehyde (CAS 1083197-78-7)
- <SC>D</SC>-Phenylalanine-<SUP>13</SUP>C<SUB>9</SUB>,<SUP>15</SUP>N (CAS 1259621-04-9)
- n-[(3,4,5-trifluorophenyl)methylidene]hydroxylamine (CAS 238743-36-7)
- 6-Methyl-5-nitropyrimidine-2,4(1H,3H)-dione (CAS 88890-66-8)
- 6-(Chloromethyl)-2,3-dihydrobenzo[b][1,4]dioxine (CAS 26309-99-9)
- Benzyl 2,4-dioxopiperidine-1-carboxylate (CAS 1246303-70-7)
- 2-(Hydroxyimino)-N-(p-tolyl)acetamide (CAS 1132-40-7)
- 5-(4-(Methylthio)benzylidene)-2-(4-propoxyphenyl)thiazolo[3,2-b][1,2,4]triazol-6(5H)-one (CAS 606962-14-5)
- 1-(2-Fluoro-6-(trifluoromethyl)pyridin-4-yl)ethan-1-one (CAS 1260679-15-9)
- N,N-(2,4-Toluene)bis-4-(2-pyridinyl)-2-piperazinecarboxylic acid (CAS 337511-96-3)
- N-(3-fluoro-2-methylphenyl)-2,2-dimethylpropanamide (CAS 811810-61-4)
- 5-Bromo-6-oxo-2-(trifluoromethyl)-1,6-dihydropyridine-3-carboxylic acid (CAS 862111-62-4)
- 3-Amino-6-methoxypicolinonitrile (CAS 1314902-70-9)
- Glucagon receptor antagonists-2 (CAS 202917-18-8)
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