n-(2,4-Difluorophenyl)-2,2,2-trifluoroacetamide CAS 98651-71-9
| CAS No. | 98651-71-9 |
| Molecular Formula | C8H4F5NO |
| Molecular Weight | 225.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
n-(2,4-Difluorophenyl)-2,2,2-trifluoroacetamide (CAS 98651-71-9), molecular formula C8H4F5NO and molecular weight 225.12 g/mol, is a CATO reference standard with documented purity and traceability.
n-(2,4-Difluorophenyl)-2,2,2-trifluoroacetamide (C8H4F5NO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures n-(2,4-Difluorophenyl)-2,2,2-trifluoroacetamide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H4F5NO |
| Molecular Weight | 225.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related n Standards
- N-(3,5-difluorophenyl)-2,2,2-trifluoroacetamide (CAS 1378573-08-0)
- N-(2,6-difluorophenyl)-2,2,2-trifluoroacetamide (CAS 98634-00-5)
- 5-(3,4-Difluorophenyl)isoxazole-3-carboxylic Acid (CAS 1017513-51-7)
- 1-(3,5-Difluorophenyl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 1038261-56-1)
- 1-(3,4-Difluorophenyl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 1038261-86-7)
- 5-(2,4-Difluorophenyl)isoxazole-3-carboxylic Acid (CAS 1083224-23-0)
- 3-(2,3-Difluorophenyl)isoxazole-5-carboxylic acid (CAS 1126636-77-8)
- 3-(2,6-Difluorophenyl)-1,2-oxazole-5-carboxylic acid (CAS 1152531-95-7)
Recommended Standards
- Ethyl 2-hydroxy-4-(trifluoromethyl)oxazole-5-carboxylate (CAS 78492-21-4)
- 7-Bromo-6,7,8,9-tetrahydro-5H-benzo[7]annulene (CAS 5200-95-3)
- 90433-27-5 1-Bromo-3-(3-methylbut-3-en-1-yl)benzene DTXSID90535472 (CAS 90433-27-5)
- 6-Bromo-1,1-dimethylindane (CAS 67159-88-0)
- 6-(Trifluoromethyl)-2H-spiro[benzofuran-3,4'-piperidin]-2'-one (CAS 2379928-12-6)
- tert-Butyl 4-(2-chloro-6-methylpyrimidin-4-yl)-3-methylpiperazine-1-carboxylate (CAS 1261235-51-1)
- Methyl 3-(4-aminophenyl)-3-methylbutanoate (CAS 1092286-42-4)
- tert-Butyl 2-(1-cyanoethyl)pyrrolidine-1-carboxylate (CAS 1781740-66-6)
- 2,2,2-Trifluoroethyl n-cyclopropylcarbamate (CAS 878259-75-7)
- Ertugliflozin Impurity 60 (CAS CATO-C4X-301160)
- 42245-37-4 (3-Methylpentyl)amine DTXSID30388888 (CAS 42245-37-4)
- Molindone (CAS 7416-34-4)
- methyl 2-{[di(pentyloxy)phosphoryl]oxy}-3,3,3-trifluoropropanoate (CAS 108682-54-8)
- Liraglutide Impurity 5 TFA Salt (CAS CATO-C4X-19925)
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