Acetaminophen Impurity 25 CAS 98966-14-4
| CAS No. | 98966-14-4 |
| Molecular Formula | C16H16N2O4 |
| Molecular Weight | 300.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Acetaminophen Impurity 25.
Acetaminophen Impurity 25 (CAS 98966-14-4) is a certified pharmaceutical impurity reference standard with the molecular formula C16H16N2O4 and a molecular weight of 300.31 g/mol.
The molecular framework of Acetaminophen Impurity 25 (C16H16N2O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H16N2O4 |
| Molecular Weight | 300.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Nitrogen Atoms | 2 |
Related Acetaminophen Standards
- Acetaminophen Impurity 19 (CAS 98966-17-7)
- Acetaminophen Dimer-d6 (CAS 1794817-30-3)
- Acetaminophen Impurity 43 (CAS CATO-C4X-121143)
- Acetaminophen Impurity 24 (CAS 1991204-56-8)
- Acetaminophen Impurity 21 (CAS 801215-24-7)
- Acetaminophen Impurity 22 (CAS CATO-C4X-121122)
- Acetaminophen-cysteine (CAS 64014-06-8)
- Acetaminophen Impurity 44 (CAS 102019-96-5)
Recommended Standards
- Paracetamol EP Impurity O (CAS 2575516-61-7)
- Paracetamol EP Impurity L (CAS 2514961-29-4)
- Rtitrexed Impurity 27 (CAS CATO-C4X-138627)
- Linezolid Impurity 41 (CAS 5394-50-3)
- Baclofen Impurity 60 (CAS CATO-C4X-101260)
- Ondansetron EP Impurity B (CAS 1076198-52-1)
- Peramivir Impurity 128 (CAS CATO-C4X-1833128)
- 6-Methyl-7-oxo-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine-2-carbonitrile (CAS 1956366-31-6)
- 4-Propyl-4H-dithieno[3,2-b:2',3'-d]pyrrole (CAS 1622311-17-4)
- 1-(4-Hydroxycinnolin-3-yl)ethanone (CAS 136920-49-5)
- 3,4-Dihydro-2H-1-benzopyran-5-ol (CAS 13849-32-6)
- ethyl N-[2,2,2-trifluoro-1-[(2-methoxyethyl)amino]-1-(trifluoromethyl)ethyl]carbamate (CAS 340033-69-4)
- (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((diphenyl(p-tolyl)methyl)amino)pentanoic acid (CAS 343770-23-0)
- Pancreatic Polypeptide (1-17)-(Ala31,Aib32)-Neuropeptide Y (18-36) (human) trifluoroacetate salt (CAS 313988-70-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com