3-(chloromethyl)-2H-chromen-2-one CAS 98994-33-3
| CAS No. | 98994-33-3 |
| Molecular Formula | C10H7ClO2 |
| Molecular Weight | 194.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-(chloromethyl)-2H-chromen-2-one.
3-(chloromethyl)-2H-chromen-2-one (CAS 98994-33-3) is a high-purity analytical reference standard with the molecular formula C10H7ClO2 and a molecular weight of 194.61 g/mol.
The molecular framework of 3-(chloromethyl)-2H-chromen-2-one (C10H7ClO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 3-(chloromethyl)-2H-chromen-2-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H7ClO2 |
| Molecular Weight | 194.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
Related chloromethyl Standards
- 2-[4-(Chloromethyl)-1,3-oxazol-2-yl]pyridine (CAS 1009563-22-7)
- 3-[4-(Chloromethyl)-1,3-oxazol-2-yl]pyridine (CAS 1009563-23-8)
- 3-(Chloromethyl)-5-phenyl-1,2,4-oxadiazole (CAS 1201-68-9)
- 5-(Chloromethyl)-3-(pyridin-3-yl)isoxazole (CAS 130775-64-3)
- 2-(Chloromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one (CAS 16867-35-9)
- 5-(Chloromethyl)-3-phenyl-1,2,4-oxadiazole (CAS 1822-94-2)
- 2-(Chloromethyl)-5-phenyl-1,3,4-oxadiazole (CAS 33575-83-6)
- 2-(Chloromethyl)quinazolin-4(3H)-one (CAS 3817-05-8)
Recommended Standards
- 2H-Chromene-3-carbonyl chloride (CAS 41873-72-7)
- 3-Chloro-4-(2-propynyloxy)benzaldehyde (CAS 443291-07-4)
- 2-Chloronaphthalene-1,4-diol (CAS 73661-09-3)
- 3-Chloropropane-1,2-diyl diacetate (CAS 869-50-1)
- (4-Benzyloxy-phenyl)-piperidin-4-yl-methanone (CAS 1263378-61-5)
- 1-(3-Amino-6-(pyridin-3-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl)-2,2-dimethylpropan-1-one (CAS 625377-69-7)
- 4-(4-Chlorophenyl)-2-phenylphthalazine-1(2H)-thione (CAS 146001-28-7)
- 2-Bromo-4-(bromomethyl)-6-(difluoromethyl)nicotinic acid (CAS 1806920-13-7)
- 5-methyl-4-[(4-methylpiperazin-1-yl)methyl]isoxazole-3-carboxylic acid,HCl (CAS 1431966-48-1)
- Dinobuton (CAS 973-21-7)
- Belzutifan Impurity 3 (CAS CATO-C4X-33943)
- Vildagliptin Impurity 101 (CAS CATO-C4X-1100101)
- N-(5-(1H-imidazol-2-yl)-2-methylphenyl)-4-(pyridin-2-ylmethoxy)benzamide (CAS 1126367-99-4)
- Insulin Degludec Impurity 2 (CAS CATO-C4X-21572)
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