1-(2,3-Dichlorophenyl)-3-(3,5-dichlorophenyl)urea CAS 99357-00-3
| CAS No. | 99357-00-3 |
| Molecular Formula | C13H8Cl4N2O |
| Molecular Weight | 350.03 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-(2,3-Dichlorophenyl)-3-(3,5-dichlorophenyl)urea (CAS 99357-00-3), molecular formula C13H8Cl4N2O and molecular weight 350.03 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-(2,3-Dichlorophenyl)-3-(3,5-dichlorophenyl)urea (C13H8Cl4N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(2,3-Dichlorophenyl)-3-(3,5-dichlorophenyl)urea meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H8Cl4N2O |
| Molecular Weight | 350.03 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Dichlorophenyl Standards
- 1-(2,5-Dichlorophenyl)-3-(3,4-dichlorophenyl)urea (CAS 13142-50-2)
- 1,2-Bis(2,4-dichlorophenyl)ethane-1,2-diamine (CAS 618092-20-9)
- N-(3,4-dichlorophenyl)-2,2-difluoro-2-(4-fluorophenoxy)acetamide (CAS 338792-46-4)
- (3,4-Dichlorophenyl)(3-methyl-5-nitrobenzofuran-2-yl)methanone (CAS 400076-04-2)
- 1'-[(3,4-Dichlorophenyl)methyl]-1',2'-dihydrospiro[1,3-dioxolane-2,3'-indole]-2'-one (CAS 866152-01-4)
- 2-[2-(3,5-Dichlorophenyl)hydrazono]-3-(4-methylphenyl)-3-oxopropanal oxime (CAS 338414-24-7)
- 3-(2,3-Dichlorophenyl)-3-(1-oxoisoindolin-2-yl)propanoic acid (CAS 885949-95-1)
- 3-(3,4-Dichlorophenyl)-3-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)propanoic acid (CAS 478260-04-7)
Recommended Standards
- 4-(2-Aminothiazol-4-yl)-2,6-dibromophenol (CAS 874606-50-5)
- Abemaciclib Impurity 126 (CAS CATO-C4X-2937126)
- N,N’-bis(3,5-dichlorophenyl)urea (CAS 73439-19-7)
- Abemaciclib Impurity 125 (CAS CATO-C4X-2937125)
- 2-(Chloromethyl)-6-cyano-3-(difluoromethyl)-4-nitropyridine (CAS 1806957-56-1)
- (6S)-6-Ethynyl-5-azaspiro[2.4]heptane (CAS 2410398-36-4)
- 5-Ethoxy-2-nitrobenzaldehyde (CAS 109134-05-6)
- 2-Hydroxy-2-phenylhexanoic acid (CAS 4445-12-9)
- (S)-2-Amino-3-(4-hydroxyphenyl)propanamide dihydrochloride (CAS 2442565-30-0)
- Gadobutrol impurity 167 (CAS CATO-C4X-2120167)
- 5-Aminooctahydrocyclopenta[c]pyrrole-5-carboxylic acid dihydrochloride (CAS 1172516-81-2)
- 1-(Naphthalen-2-yl)-5-phenyl-1H-pyrazole-3-carboxylic acid (CAS 62160-34-3)
- Methyl 4-{[2-(3-piperidinyl)ethoxy]-methyl}benzoate hydrochloride (CAS 1220032-41-6)
- Semaglutide Impurity 10 (CAS CATO-C4X-222610)
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