(1R,3r,5S)-Ipratropium Impurity 40 CAS 99888-00-3
| CAS No. | 99888-00-3 |
| Molecular Formula | C18H25NO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies (1R,3r,5S)-Ipratropium Impurity 40 (CAS 99888-00-3), a pharmacopoeial impurity reference standard (molecular formula C18H25NO3HCl, MW 339.86 g/mol) used for the identification and quantification of trace impurities in APIs.
(1R,3r,5S)-Ipratropium Impurity 40 (C18H25NO3HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), (1R,3r,5S)-Ipratropium Impurity 40 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H25NO3 HCl |
| Molecular Weight | 339.86 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
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- 2-(4-Methyl-2,5-dioxo-4-phenethylimidazolidin-1-yl)acetonitrile (CAS 956366-30-6)
- 1-Chloro-3-phenylpropan-2-ol (CAS 5396-65-6)
- 2-Methyldodecane (CAS 1560-97-0)
- 2-(4-Amino-2,5-dimethylphenyl)-6-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione (CAS 831227-52-2)
- 4-(1-Aminoethyl)-N,N-diethylbenzene-1-sulfonamide hydrochloride (CAS 1193389-59-1)
- Des-Ser39-Tirzepatide (CAS CATO-CPTD788936)
Why CATO?
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