Argatroban Impurity 1 CAS CATO-C4X-10071
| CAS No. | CATO-C4X-10071 |
| Molecular Formula | C20H25NO4S |
| Molecular Weight | 375.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Argatroban Impurity 1 (CAS CATO-C4X-10071) is a certified pharmaceutical impurity reference standard with the molecular formula C20H25NO4S and a molecular weight of 375.48 g/mol.
The molecular framework of Argatroban Impurity 1 (C20H25NO4S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H25NO4S |
| Molecular Weight | 375.48 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Argatroban Standards
- Argatroban Impurity 50 (CAS CATO-C4X-100750)
- Argatroban Impurity 70 (CAS CATO-C4X-100770)
- Argatroban Impurity N2 (CAS 79672-38-1)
- Argatroban Impurity 113 (Mixture of Diastereomers) (CAS CATO-C4X-1007113)
- Argatroban Impurity 143 (CAS CATO-C4X-1007143)
- Argatroban Impurity 111 (CAS CATO-C4X-1007111)
- Argatroban Impurity 39 (Mixture of Diastereomers) (CAS 184043-01-4)
- Argatroban Impurity 110 (CAS CATO-C4X-1007110)
Recommended Standards
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- 5-Amino-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-imidazole-4-carbonitrile (CAS 23192-63-4)
- 4-(2-(trifluoromethyl)phenyl)butanoic acid (CAS 899350-21-1)
- 6-Fluoro-3-methyl-2,3-dihydro-1H-inden-1-one (CAS 162549-02-2)
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