Ibrutinib Impurity 76 CAS CATO-C4X-106476
| CAS No. | CATO-C4X-106476 |
| Molecular Formula | C37H47N7O5 |
| Molecular Weight | 669.81 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Ibrutinib Impurity 76 (C37H47N7O5) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Ibrutinib Impurity 76 (CAS CATO-C4X-106476) is a certified pharmaceutical impurity reference standard with the molecular formula C37H47N7O5 and a molecular weight of 669.81 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C37H47N7O5 |
| Molecular Weight | 669.81 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 7 |
Related Ibrutinib Standards
- Ibrutinib Impurity 68 (CAS CATO-C4X-106468)
- Ibrutinib Impurity 173 (CAS CATO-C4X-1064173)
- Ibrutinib Impurity 16 (CAS CATO-C4X-106416)
- Ibrutinib Impurity 119 (CAS CATO-C4X-1064119)
- Ibrutinib Impurity 23 (CAS CATO-C4X-106423)
- Ibrutinib Impurity 176 (CAS CATO-C4X-1064176)
- Ibrutinib Impurity 111 (CAS CATO-C4X-1064111)
- Ibrutinib Impurity 91 (CAS CATO-C4X-106491)
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