Erlotinib impurity 133 CAS CATO-C4X-1069133
| CAS No. | CATO-C4X-1069133 |
| Molecular Formula | C15H24N2O6 |
| Molecular Weight | 328.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Erlotinib impurity 133 (C15H24N2O6) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 328.36 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Erlotinib impurity 133 (CAS CATO-C4X-1069133) is a certified pharmaceutical impurity reference standard with the molecular formula C15H24N2O6 and a molecular weight of 328.36 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H24N2O6 |
| Molecular Weight | 328.36 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related Erlotinib Standards
- Erlotinib impurity 132 (CAS CATO-C4X-1069132)
- Erlotinib Impurity 60 (CAS CATO-C4X-106960)
- ErlotiniB impurity 35 (CAS CATO-C4X-106935)
- Erlotinib Impurity 42 (CAS 501684-22-6)
- Erlotinib Impurity 47 (CAS 179688-26-7)
- Erlotinib Impurity 67 (CAS CATO-C4X-106967)
- Erlotinib Impurity 68 (CAS CATO-C4X-106968)
- Erlotinib Impurity 135 (CAS CATO-C4X-1069135)
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