Tadalafil Impurity 57 CAS CATO-C4X-108757
| CAS No. | CATO-C4X-108757 |
| Molecular Formula | C22H20N2O6 |
| Molecular Weight | 408.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Tadalafil Impurity 57 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Tadalafil Impurity 57 (CAS CATO-C4X-108757), a pharmacopoeial impurity reference standard (molecular formula C22H20N2O6, MW 408.40 g/mol) used for the identification and quantification of trace impurities in APIs.
Tadalafil Impurity 57 (C22H20N2O6) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tadalafil Impurity 57 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H20N2O6 |
| Molecular Weight | 408.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related Tadalafil Standards
- Tadalafil impurity 126 (CAS CATO-C4X-1087126)
- Tadalafil Impurity 171 (CAS CATO-C4X-1087171)
- Tadalafil Impurity 106 (CAS 1356345-67-9)
- Tadalafil Impurity N1 (CAS 1220393-12-3)
- Tadalafil Impurity 173 (CAS CATO-C4X-1087173)
- Tadalafil EP Impurity I (CAS 2378614-29-8)
- Tadalafil Impurity N98 (CAS 1795790-92-9)
- Tadalafil Impurity 139 (CAS CATO-C4X-1087139)
Recommended Standards
- (2S,3R,4S,5S,6R)-2-(5-((E)-2-(3,5-dihydroxyphenyl)vinyl-1,2-d2)-2-hydroxyphenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (CAS CATO-C3D-262428)
- Gefitinib Impurity 82 (CAS CATO-C4X-111782)
- Villosol (CAS 60077-62-5)
- Irinotecan Impurity 64 (CAS CATO-C4X-166764)
- Rivaroxaban Impurity 206 (CAS CATO-C4X-1090206)
- Saxagliptin Impurity 25 (CAS CATO-C4X-104925)
- Piribedil Impurity 5 (CAS CATO-C4X-28137)
- 4,6-Dibromo-2-nitrobenzofuran-7-ol (CAS 96089-26-8)
- 6'-(5-Amino-2-methylphenyl)-2'-chloro-5',6'-dihydro-7'H-spiro[cyclopropane-1,8'-pyrido[4,3-d]pyrimidin]-7'-one (CAS 3064091-82-0)
- 1'-Methyl-2'-oxospiro[cyclopropane-1,3'-indoline]-2-carboxylic acid (CAS 1780272-54-9)
- Pyridinediamine, ar-bromo- (CAS 114292-91-0)
- 3-(4-Bromophenoxy)-1-methylpyrrolidine (CAS 486422-46-2)
- Fenbufen EP Impurity D (CAS CATO-C4X-19393)
- Macrophage Inhibitory Peptide (CAS 41961-56-2)
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