N-Nitroso Felodipine Impurity 22 CAS CATO-C4X-109422
| CAS No. | CATO-C4X-109422 |
| Molecular Formula | C15H12Cl2N2O5 |
| Molecular Weight | 371.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 371.17 g/mol gives N-Nitroso Felodipine Impurity 22 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, N-Nitroso Felodipine Impurity 22 (CAS CATO-C4X-109422, C15H12Cl2N2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
N-Nitroso Felodipine Impurity 22 (C15H12Cl2N2O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), N-Nitroso Felodipine Impurity 22 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H12Cl2N2O5 |
| Molecular Weight | 371.17 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related N Standards
- N-Nitroso Propafenone (CAS 3036581-87-7)
- Nitroso Perindopril EP impurity B (CAS CATO-C4X-125246)
- 3-[Nitroso(benzyloxy)amino]-N-[(benzyloxy)carbonyl]-D,L-alanine (CAS 1286490-16-1)
- 3-[Nitroso(benzyloxy)amino]-N-[(benzyloxy)carbonyl]-L-alanine (CAS 832090-73-0)
- N-Nitroso-(S,S)-Formoterol (CAS CATO-C4X-152583)
- N-Nitroso-(R,R)-Formoterol (CAS CATO-C4X-152584)
- N-Nitroso Clozapine EP Impurity D (CAS CATO-C4X-134017)
- N-nitroso-propafenone impurity B (CAS CATO-C4X-132237)
Recommended Standards
- Ethyl 4-(benzyloxy)-5-bromo-2,3-difluorobenzoate (CAS 2404733-88-4)
- Ethyl 6-bromo-8-(2-ethoxy-2-oxoethoxy)imidazo[1,2-a]pyridine-3-carboxylate (CAS 1804976-79-1)
- Ethyl 5-amino-1-benzyl-4-iodo-1H-pyrazole-3-carboxylate (CAS 1427014-06-9)
- tert-Butyl 3-bromo-5-methoxy-6-nitro-1H-indole-1-carboxylate (CAS 1822816-83-0)
- Fosfomycin Impurity 42 (CAS 45629-00-3（free base）)
- Salbutamol Impurity 111 (CAS CATO-C4X-1176111)
- Benzbromarone Impurity 27 (CAS CATO-C4X-225027)
- Methyl 4'-amino-3'-fluoro[1,1'-biphenyl]-3-carboxylate (CAS 889946-51-4)
- 3-([1,1'-Biphenyl]-4-yl)-4-hydroxy-1H-pyrrole-2,5-dione (CAS 77529-41-0)
- Methyl 5-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-oxopentanoate (CAS 1083229-77-9)
- (5H-Pyrrolo[2,3-b]pyrazin-6-yl)methanamine (CAS 1517288-51-5)
- 2-Amino-1-(4-methoxyphenyl)-4,5-dimethyl-1h-pyrrole-3-carbonitrile (CAS 72578-38-2)
- rac-syn N,N-Diethyl Norephedrine (CAS 34154-81-9)
- Semaglutide impurity 195 (CAS CATO-C4X-2226195)
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