Vildagliptin Impurity 72 CAS CATO-C4X-110072
| CAS No. | CATO-C4X-110072 |
| Molecular Formula | C14H19ClN4O3 |
| Molecular Weight | 326.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Vildagliptin Impurity 72.
As a process- or degradation-related impurity, Vildagliptin Impurity 72 (CAS CATO-C4X-110072, C14H19ClN4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Vildagliptin Impurity 72 (C14H19ClN4O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Vildagliptin Impurity 72 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H19ClN4O3 |
| Molecular Weight | 326.78 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Vildagliptin Standards
- Vildagliptin Impurity 3 (CAS 565453-40-9)
- Vildagliptin Impurity 114 (R-Isomer) (CAS CATO-C4X-1100114)
- Vildagliptin Impurity 4 (CAS 565453-39-6)
- Vildagliptin Impurity 90 (CAS CATO-C4X-110090)
- Vildagliptin Impurity 76 (CAS 3034601-47-0)
- Vildagliptin Impurity 77 (CAS CATO-C4X-110077)
- Vildagliptin Impurity 16 (CAS CATO-C4X-110016)
- Vildagliptin Impurity 21 (CAS CATO-C4X-110021)
Recommended Standards
- tert-Butyl (S)-(9-chloro-5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)carbamate (CAS 889458-98-4)
- Domperidone Impurity 37 (CAS CATO-C4X-142037)
- N-Benzyl-2-((5-chloroquinolin-8-yl)oxy)acetamide (CAS 88350-51-0)
- (2-(3-(aminomethyl)-5-methyl-4H-1,2,4-triazol-4-yl)-5-chlorophenyl)(phenyl)methanone (CAS CATO-C4X-146028)
- Dronedarone Impurity 13 (CAS 748763-03-3)
- Entacapone Impurity 31 (CAS 80547-69-9)
- Abrocitinib Impurity 41 (CAS 2504210-45-9)
- tert-Butyldimethyl((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)but-3-en-2-yl)oxy)silane (CAS 277331-69-8)
- N-(5-(4-Chlorophenyl)-1,3,4-thiadiazol-2-yl)-3-phenylpropanamide (CAS 476463-64-6)
- 5-((4-Chlorophenyl)sulfonyl)-2-(propylthio)thiazol-4-amine (CAS 494763-20-1)
- (3-(Azetidin-1-ylmethyl)phenyl)(2,3-dichlorophenyl)methanone (CAS 898772-06-0)
- 3-(5-(2-Bromophenyl)-1,2,4-oxadiazol-3-yl)morpholine (CAS 1707605-78-4)
- ETHYL 6-CHLOROOXOINDOLINE-3-CARBOXYLATE (CAS 14750-18-6)
- Insulin Degludec Impurity 28 (CAS CATO-C4X-215728)
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