Gefitinib Impurity 34 CAS CATO-C4X-111734
| CAS No. | CATO-C4X-111734 |
| Molecular Formula | C22H24ClFN4O3 |
| Molecular Weight | 446.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Gefitinib Impurity 34 (CAS CATO-C4X-111734, C22H24ClFN4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Gefitinib Impurity 34 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 446.90 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures Gefitinib Impurity 34 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H24ClFN4O3 |
| Molecular Weight | 446.90 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Gefitinib Standards
- Gefitinib (CAS 184475-35-2)
- Gefitinib Impurity 10 (CAS 1603814-04-5)
- Gefitinib Impurity 33 (CAS 909863-33-8)
- Gefitinib Impurity 37 (CAS CATO-C4X-111737)
- Gefitinib Impurity 43 (CAS CATO-C4X-111743)
- Gefitinib Impurity 93 (CAS CATO-C4X-111793)
- Gefitinib Impurity 15 (CAS 1608115-59-8)
- Gefitinib Impurity 39 (CAS CATO-C4X-111739)
Recommended Standards
- N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-((4-ethyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 566188-43-0)
- 4-[5-(4-Chlorophenyl)-1H-pyrazol-3-yl]-1-(2-nitrobenzenesulfonyl)piperidine (CAS 1025770-01-7)
- Undecamethylcyclohexasiloxan-2-ol DISCONTINUED (CAS 141102-71-8)
- 2-(3-Chlorophenyl)-4-(3-(4-(methylthio)phenyl)-1,2,4-oxadiazol-5-yl)phthalazin-1(2H)-one (CAS 1291859-96-5)
- Alanyl Glutamine Impurity 44 TFA Salt (CAS CATO-C4X-197444)
- Voriconazole Impurity 87 (CAS CATO-C4X-136687)
- Baricitinib Impurity 73 (CAS CATO-C4X-226073)
- 2-Bromo-5-cyclopropoxynicotinamide (CAS 1243468-34-9)
- (5-(((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-4,5-dihydroisoxazol-3-yl)methyl 4-chlorobenzoate (CAS 338422-35-8)
- 4-Ethyl-1-methyl-1H-pyrrole-2-carbonitrile (CAS 123476-65-3)
- 3-Chloro-5-cyclopropoxy-N,N-dimethylisonicotinamide (CAS 1243329-71-6)
- Ethyl 5-methoxy-2-nitrobenzoate (CAS 10399-67-4)
- 5-(Ethylsulfonyl)-4-(4-fluorophenyl)-1H-thieno[2,3-c]pyrazol-3-amine (CAS 1708179-11-6)
- Gastric Inhibitory Polypeptide (human) (CAS 100040-31-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com