Palbociclib Impurity 187 CAS CATO-C4X-1125187
| CAS No. | CATO-C4X-1125187 |
| Molecular Formula | C22H26BrN7O |
| Molecular Weight | 484.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Palbociclib Impurity 187 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Palbociclib Impurity 187 (CAS CATO-C4X-1125187, C22H26BrN7O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution, Palbociclib Impurity 187 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 484.39 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H26BrN7O |
| Molecular Weight | 484.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 7 |
Related Palbociclib Standards
- Palbociclib Impurity 109 (CAS 1974279-20-3)
- Palbociclib Impurity 8 (CAS CATO-C4X-11258)
- Palbociclib Impurity 145 (CAS CATO-C4X-1125145)
- Palbociclib Impurity 80 (CAS CATO-C4X-112580)
- Palbociclib Impurity 154 (CAS CATO-C4X-1125154)
- Palbociclib Impurity 101 (CAS CATO-C4X-1125101)
- Palbociclib Impurity 125 (CAS CATO-C4X-1125125)
- Palbociclib impurity 128 (CAS CATO-C4X-1125128)
Recommended Standards
- (11β)-11,17a-Dihydroxy-17a-[(phosphonooxy)methyl]-D-homoandrosta-1,4-diene-3,17-dione Disodium Salt DISCONTINUED. Please see D455580. (CAS 96700-79-7)
- Nicergoline (CAS 27848-84-6)
- 1-[4-Nitro-3-(trifluoromethyl)phenyl]-4-{5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}piperidine (CAS 1026780-29-9)
- Nicergoline Impurity 26 (CAS CATO-C4X-208526)
- Tobramycin Impurity 20 (CAS CATO-C4X-220020)
- Brimonidine Impurity 31 (CAS CATO-C4X-156631)
- Vildagliptin Impurity 104 (CAS CATO-C4X-1100104)
- [(4-chloropyridin-2-yl)methyl](methyl)(propan-2-yl)amine (CAS 1503034-07-8)
- 6-methoxy-1,2,3,4-tetrahydroquinoline-2,4-dione (CAS 1188436-95-4)
- 2-((tert-Butoxycarbonyl)amino)-2-methylbutanoic acid (CAS 139937-98-7)
- 4-Fluoro-3-(3-methoxyphenyl)benzoic acid (CAS 1181452-19-6)
- 4-(prop-1-en-2-yl)oxan-4-ol (CAS 521275-90-1)
- 4,4'-Dibromo-4''-tert-butyltriphenylamine (CAS 852534-22-6)
- Semaglutide impurity 34 (CAS CATO-C4X-222634)
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