Tocopherol impurity 40 CAS CATO-C4X-119540
| CAS No. | CATO-C4X-119540 |
| Molecular Formula | C33H56O3 |
| Molecular Weight | 500.80 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Tocopherol impurity 40 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Tocopherol impurity 40 (CAS CATO-C4X-119540, C33H56O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Tocopherol impurity 40 (C33H56O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C33H56O3 |
| Molecular Weight | 500.80 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
Related Tocopherol Standards
- Alpha-Tocopherol-D6 Acetate (CAS 143731-16-2)
- Tocopherol Impurity 20 (CAS 7695-91-2)
- Tocopherol Impurity 36 (CAS CATO-C4X-119536)
- D-α-Tocopherol Succinate (CAS 4345-03-3)
- alpha-Tocopherol quinol (CAS 14745-36-9)
- Tocopherol Impurity 30 (CAS CATO-C4X-119530)
- Tocopherol Impurity 31 (CAS CATO-C4X-119531)
- δ-Tocopherol Acetate (CAS 13027-26-4)
Recommended Standards
- CAS 326495-47-0 (CAS 326495-47-0)
- 3β[N-(N',N'-Dimethylaminoethane)-carbamoyl]cholesterol (CAS 137056-72-5)
- N-(3-Bromophenyl)-2-((4-(4-chlorophenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 476483-91-7)
- 2-(4-Bromobenzenesulfonyl)-3-(4-chlorobenzenesulfonyl)-4,6-dimethylpyridine (CAS 478262-71-4)
- Pitavastatin Impurity 22 (CAS CATO-C4X-103722)
- Tedizolid Impurity 75 (CAS CATO-C4X-105475)
- Solifenacin Impurity 8 (CAS CATO-C4X-10538)
- (-)-N-((2,5-Dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl)carbamoyl)-2,6-difluorobenzamide (CAS 130841-26-8)
- tert-Butyl 4-((3-methylpyrazin-2-yl)oxy)piperidine-1-carboxylate (CAS 1261235-06-6)
- N-benzyl-3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propanamide (CAS 1980087-07-7)
- 3-Fluoro-N-(3-methylbutan-2-yl)aniline (CAS 1019518-07-0)
- 2-(Benzylamino)-N-(3,5-dimethylphenyl)-2-thioxoacetamide (CAS 329079-46-1)
- Ethyl 2-[(2,6-dimethylphenyl)carbamoyl]-2-acetamidoacetate (CAS 866017-97-2)
- Neuropeptide S (rat) (CAS 412938-75-1)
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