Isavuconazole Impurity 228 CAS CATO-C4X-1236228
| CAS No. | CATO-C4X-1236228 |
| Molecular Formula | C35H37F2N8O6S |
| Molecular Weight | 735.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Isavuconazole Impurity 228 (CAS CATO-C4X-1236228) is a certified pharmaceutical impurity reference standard with the molecular formula C35H37F2N8O6S and a molecular weight of 735.78 g/mol.
The molecular framework of Isavuconazole Impurity 228 (C35H37F2N8O6S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Isavuconazole Impurity 228 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C35H37F2N8O6S |
| Molecular Weight | 735.78 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 20.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
| Sulfur Atoms | 1 |
Related Isavuconazole Standards
- Isavuconazole Impurity 124 (CAS CATO-C4X-1236124)
- Isavuconazole impurity 164 (CAS CATO-C4X-1236164)
- Isavuconazole Impurity 205 (CAS CATO-C4X-1236205)
- Isavuconazole Impurity 6 (CAS CATO-C4X-12366)
- Isavuconazole Impurity 210 (CAS CATO-C4X-1236210)
- Isavuconazole Impurity 126 (CAS CATO-C4X-1236126)
- Isavuconazole Impurity 34 (CAS CATO-C4X-123635)
- Isavuconazole Impurity 22 (CAS CATO-C4X-123622)
Recommended Standards
- Benzyl (S)-11-benzyl-1-(9H-fluoren-9-yl)-3,6,9,12,15-pentaoxo-2,18-dioxa-4,7,10,13,16-pentaazaicosan-20-oate (CAS 2264011-97-2)
- Rilapladib - API Standards (CAS 412950-08-4)
- Docetaxel Impurity 28(N-Formyl impurity) (CAS CATO-C4X-161928)
- Cabazitaxel Impurity 25 (CAS 1638286-64-2)
- Vortioxetine Impurity 110 (CAS 27758-55-0)
- Doxazosin EP Impurity E (CAS 27631-29-4)
- Olprinone Impurity 9 (CAS 885275-62-7)
- [1,3-Bis(2,6-diisopropylphenyl)-imidazolidinylidene][1,3-divinyl-1,1,3,3-tetramethyldisiloxane]platinum(0) (CAS 873311-51-4)
- GrossaMide (CAS 80510-06-1)
- (3-(3-(Thiophen-2-ylthio)-1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl)methanol (CAS 858117-36-9)
- 2-Chloro-1-(3-(dimethylamino)pyrrolidin-1-yl)ethanone (CAS 1341539-96-5)
- Almotriptan Impurity 14 (CAS CATO-C4X-153814)
- 2,6,6-Trimethyl-2-Cyclohexene-1,4-Dione (CAS 1125-21-9)
- Insulin Degludec Impurity 20 (CAS CATO-C4X-215720)
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