Efinaconazole Impurity 22 CAS CATO-C4X-124322
| CAS No. | CATO-C4X-124322 |
| Molecular Formula | C18H20F2N4 |
| Molecular Weight | 330.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Efinaconazole Impurity 22.
Efinaconazole Impurity 22 (CAS CATO-C4X-124322) is a certified pharmaceutical impurity reference standard with the molecular formula C18H20F2N4 and a molecular weight of 330.38 g/mol.
Structurally, Efinaconazole Impurity 22 (C18H20F2N4) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 330.38 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H20F2N4 |
| Molecular Weight | 330.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Efinaconazole Standards
- Efinaconazole impurity 43 (CAS CATO-C4X-124343)
- Efinaconazole impurity 44 (CAS CATO-C4X-124344)
- Efinaconazole impurity 45 (CAS CATO-C4X-124345)
- Efinaconazole Impurity 11 (CAS CATO-C4X-124311)
- Efinaconazole Impurity 31 (CAS CATO-C4X-124331)
- Efinaconazole Impurity 13 (CAS CATO-C4X-124313)
- Efinaconazole Impurity 40 (CAS 161287-08-7)
- Efinaconazole impurity 52 (CAS CATO-C4X-124352)
Recommended Standards
- Anastrozole Impurity 15 (CAS 2469244-33-3)
- N-Nitroso Dobutamine (CAS CATO-C4X-129838)
- Brexpiprazole Impurity 109 (CAS CATO-C4X-1131109)
- Enalapril Maleate Impurity 26 (CAS 115623-21-7)
- Brexpiprazole Impurity 93 (CAS CATO-C4X-113193)
- Indapamide Impurity 17 (CAS 2494-79-3)
- Tedizolid Impurity 75 (CAS CATO-C4X-105475)
- 3-(Propan-2-yl)-1,2-oxazole-4-carbaldehyde (CAS 1539696-86-0)
- Levofolinate Impurity 11 monocalcium salt (CAS CATO-C4X-133511)
- 3,5-Difluoro-N-methoxy-N-methylbenzamide (CAS 874889-34-6)
- 2,2'-(Ethane-1,2-diyl)dibenzoic acid (CAS 4281-17-8)
- 2-chloro-1-(1-isoxazol-3-yl-2,5-dimethyl-1H-pyrrol-3-yl)ethanone (CAS 857041-83-9)
- N-(3-Fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide p-toluenesulfonate (CAS 1394820-77-9)
- Acetyl Dipeptide-1 (CAS 196604-48-5)
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