Bisoprolol EP Impurity B HCl CAS CATO-C4X-124740
| CAS No. | CATO-C4X-124740 |
| Molecular Formula | C18H31NO4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Bisoprolol EP Impurity B HCl (CAS CATO-C4X-124740), a pharmacopoeial impurity reference standard (molecular formula C18H31NO4HCl, MW 361.91 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, Bisoprolol EP Impurity B HCl is typically white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 361.91 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H31NO4 HCl |
| Molecular Weight | 361.91 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Bisoprolol Standards
- Bisoprolol Impurity 79 (CAS 1039828-27-7)
- Bisoprolol Fumarate (CAS 104344-23-2)
- Bisoprolol-D6 Fumarate (CAS 104344-23-2(Unlabelled))
- Bisoprolol Impurity 49 (CAS 104857-48-9)
- Bisoprolol Fumarate (CAS 105878-43-1)
- Bisoprolol Impurity 62 Formate (CAS 109791-18-6(free base))
- Bisoprolol Impurity N5 (CAS 109791-19-7)
- Bisoprolol EP Impurity T (CAS 1173203-26-3)
Recommended Standards
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- Brimonidine Impurity 17 (CAS 134862-75-2)
- Trimipramine-d3 Maleate (CAS 1185245-93-5)
- (2-Methylthiazol-4-yl)boronic acid (CAS 1246761-85-2)
- Avibactam Impurity 122 (CAS CATO-C4X-1348122)
- Semaglutide Impurity 144 (CAS 394210-59-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com