Clomipramine HCl EP Impurity A DiHCl CAS CATO-C4X-12653
| CAS No. | CATO-C4X-12653 |
| Molecular Formula | C23H32ClN3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 422.44 g/mol gives Clomipramine HCl EP Impurity A DiHCl distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Clomipramine HCl EP Impurity A DiHCl (CAS CATO-C4X-12653, C23H32ClN3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Clomipramine HCl EP Impurity A DiHCl (C23H32ClN3HCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Clomipramine HCl EP Impurity A DiHCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H32ClN3 2*HCl |
| Molecular Weight | 422.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Clomipramine Standards
- Clomipramine Impurity 8 (CAS 109-54-6)
- Clomipramine EP Impurity D Hydrochloride (CAS 115189-28-1)
- Clomipramine-d6 N-Oxide (CAS 1189479-06-8)
- Clomipramine-d6 Hydrochloride (CAS 1189882-28-7)
- Clomipramine-D3 (CAS 136765-29-2)
- Clomipramine-d3 HCl (N-methyl-d3) (CAS 1398065-86-5)
- Clomipramine N-Oxide (CAS 14171-67-6)
- Clomipramine Hydrochloride EP Impurity C (CAS 1425793-87-8)
Recommended Standards
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- Penfluridol Impurity 4 (CAS CATO-C4X-35384)
- Doxepin Impurity 2 (CAS 131523-93-8)
- 3,5-Diisobutyl-1,2,4-trithiolane (CAS 92900-67-9)
- 2-Bromo-5-methoxyaniline Hydrochloride (CAS 129968-11-2)
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- Ethyl 1-(pent-4-en-1-yl)-1H-pyrazole-4-carboxylate (CAS 1052103-95-3)
- Procaine Impurity 18 (CAS CATO-C4X-262318)
- 3-Bromo-5-sulfamoylbenzoic acid (CAS 83173-96-0)
- [Formaldehyde Schiff-base]-Semaglutide Impurity 136 X TFA Salt (CAS CATO-C4X-2226136)
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