Propafenone Impurity 24 CAS CATO-C4X-132224
| CAS No. | CATO-C4X-132224 |
| Molecular Formula | C21H25NO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Propafenone Impurity 24 (C21H25NO3C2HF3O2) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Propafenone Impurity 24 (CAS CATO-C4X-132224) is a certified pharmaceutical impurity reference standard with the molecular formula C21H25NO3C2HF3O2 and a molecular weight of 453.46 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H25NO3 C2HF3O2 |
| Molecular Weight | 453.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Propafenone Standards
- (R)-Propafenone (CAS 107381-31-7)
- (S)-Propafenone (CAS 107381-32-8)
- (R)-Propafenone HCl (CAS 107381-35-1)
- (S)-Propafenone HCl (CAS 107381-36-2)
- Propafenone-D7 Hydrochloride (CAS 1219799-06-0)
- Propafenone EP Impurity F (CAS 1329643-40-4)
- Propafenone Dimer Impurity-d10 (CAS 1346602-27-4)
- Propafenone EP Impurity G (CAS 1346603-80-2)
Recommended Standards
- Flurbiprofen Impurity 110 (CAS CATO-C4X-1444110)
- Olprinone Impurity 9 (CAS 885275-62-7)
- Sovateltide Impurity 1 (CAS CATO-C4X-34651)
- 5-Bromo-4-cyano-2-methoxyphenyl acetate (CAS 515832-53-8)
- Hydroxychloroquine Impurity 23 (CAS 69559-11-1)
- 2-((Fluoroiodomethyl)sulfonyl)pyridine (CAS 1415115-02-4)
- 2-Bromo-N,N-diethyl-4,5-difluorobenzenesulfonamide (CAS 1704065-69-9)
- Pazopanib Impurity 11 Dihydrate (CAS 80927-55-5(free base))
- N-(m-Tolyl)hydrazinecarboxamide (CAS 15940-62-2)
- Semaglutide impurity 201 (CAS CATO-C4X-2226201)
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