Nafamostat Impurity 10 CAS CATO-C4X-133210
| CAS No. | CATO-C4X-133210 |
| Molecular Formula | C19H17N5O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Nafamostat Impurity 10 (CAS CATO-C4X-133210) is a certified pharmaceutical impurity reference standard with the molecular formula C19H17N5O2HCl and a molecular weight of 383.84 g/mol.
The molecular framework of Nafamostat Impurity 10 (C19H17N5O2HCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nafamostat Impurity 10 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H17N5O2 HCl |
| Molecular Weight | 383.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Nafamostat Standards
- Nafamostat Impurity 61 (CAS 1026613-65-9)
- Nafamostat impurity 110 (CAS 107490-62-0)
- Nafamostat Impurity 65 (CAS 107490-62-0（free base）)
- Nafamostat Impurity N3 (CAS 115325-88-7)
- Nafamostat Impurity 26 (CAS 1192026-58-6)
- Nafamostat Impurity 63 (CAS 121714-82-7)
- Nafamostat Impurity 37 (CAS 122228-09-5)
- Nafamostat Impurity 35 (CAS 130200-58-7)
Recommended Standards
- Relebactam Impurity 12 (CAS 1190363-52-0)
- Doxepin EP Impurity D (CAS 3607-18-9)
- Fezolinetant Impurity 16 (CAS CATO-C4X-327016)
- Ethyl 2-(5-methoxypyridin-2-yl)pyrimidine-5-carboxylate (CAS 1447606-14-5)
- Disulfamide (CAS 671-88-5)
- 4,8-Dimethyl-1,2,5,6-tetrahydro-3H-pyrido[1,2-a]quinolin-3-one (CAS 194979-95-8)
- 2-ethoxy-3-(trifluoromethyl)pyridine (CAS 849934-82-3)
- 1-O-Octadecyl-sn-glycerol (CAS 6129-13-1)
- Oxymetazoline Impurity 13 (CAS CATO-C4X-172313)
- Erythropoietin Mimetic Peptide Sequence 20 (CAS 203397-62-0)
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