Clindamycin Impurity 81 CAS CATO-C4X-134181
| CAS No. | CATO-C4X-134181 |
| Molecular Formula | C18H32Cl2N2O4S |
| Molecular Weight | 443.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Clindamycin Impurity 81 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Clindamycin Impurity 81 (CAS CATO-C4X-134181, C18H32Cl2N2O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Clindamycin Impurity 81 (C18H32Cl2N2O4S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H32Cl2N2O4S |
| Molecular Weight | 443.43 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Clindamycin Standards
- Clindamycin Impurity 134 (CAS CATO-C4X-1341134)
- Clindamycin Impurity 59 (CAS CATO-C4X-134159)
- Clindamycin Impurity 72 (CAS CATO-C4X-134172)
- Clindamycin Impurity 87 (CAS CATO-C4X-134187)
- Clindamycin Impurity 88 (CAS CATO-C4X-134188)
- Clindamycin Sulfoxide (S-Isomer) (CAS 887607-49-0)
- Clindamycin Impurity 151 (CAS CATO-C4X-1341151)
- Clindamycin Sulfoxide (R-Isomer) (CAS 887607-53-6)
Recommended Standards
- Cefminox Impurity 5 (CAS CATO-C4X-19265)
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- Linezolid Impurity 73 (CAS CATO-C4X-107373)
- Zopiclone impurity 28 (CAS 69433-07-4)
- Telmisartan Impurity 57 (CAS 884330-16-9)
- Difelikefalin Impurity 64 (CAS 2269512-88-9)
- (Z)-3-(((4-chlorobenzyl)oxy)imino)-1-phenylindolin-2-one (CAS 341964-28-1)
- 2-(2,6-Dichlorobenzylidene)hydrazine-1-carbothioamide (CAS 24047-22-1)
- 4,6-Dichloro-N-methyl-N-phenylpyrimidin-2-amine (CAS 7038-66-6)
- 3-Amino-2-(4-isopropylbenzyl)propanoic acid (CAS 1260605-99-9)
- 1-Phenylpropane-2-thiol (CAS 4475-55-2)
- 2,3-Dihydroxy-1-(1H-indol-3-yl)propan-1-one (CAS 6360-94-7)
- (Pro3)-Gastric Inhibitory Polypeptide (human) trifluoroacetate salt (CAS 299898-52-5)
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