Lercanidipine Impurity 8 HCl CAS CATO-C4X-13648
| CAS No. | CATO-C4X-13648 |
| Molecular Formula | C36H39N3O6 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Lercanidipine Impurity 8 HCl (C36H39N3O6HCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Lercanidipine Impurity 8 HCl (CAS CATO-C4X-13648, C36H39N3O6HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C36H39N3O6 HCl |
| Molecular Weight | 646.18 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Lercanidipine Standards
- Lercanidipine Impurity 36 (CAS 100427-26-7)
- Lercanidipine Impurity 60 (CAS 100427-51-8)
- Lercanidipine Impurity 7 (CAS 100442-33-9)
- Lercanidipine Impurity 38 (CAS 10317-10-9)
- Lercanidipine Impurity 19 (CAS 111304-32-6)
- Lercanidipine Impurity 5 (CAS 1119226-97-9)
- Lercanidipine-d3 Hydrochloride (CAS 1189954-18-4)
- (+/-) Lercanidipine D3 (CAS 1190043-34-5)
Recommended Standards
- Telmisartan EP Impurity I (CAS 528560-93-2)
- Baloxavir Impurity 134 (CAS CATO-C4X-2108134)
- Reserpine impurity 8 (CAS CATO-C4X-14048)
- 3-[(2-Chloro-4-fluorobenzyl)sulfonyl]-propanoic acid (CAS 702670-31-3)
- n-(4-Bromo-3-methylbenzyl)-3-methylbutan-1-amine (CAS 1027215-41-3)
- CIS-METHYL 2-(4-((TERT-BUTOXYCARBONYL)AMINO)CYCLOHEXYL)ACETATE (CAS 913748-13-7)
- (1S,4AS,5S,7R,7aR)-1-methoxy-7-methyloctahydrocyclopenta[c]pyran-5,7-diol (CAS 55732-36-0)
- (4-Methylthiazol-5-yl)methanamine dihydrochloride (CAS 1082705-62-1)
- 3-(4-Bromophenyl)-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-one (CAS 84770-66-1)
- Peptide Impurity 05 (CAS 2322924-83-2)
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