Voriconazole Impurity 88 CAS CATO-C4X-136688
| CAS No. | CATO-C4X-136688 |
| Molecular Formula | C19H21ClF3N5OSi |
| Molecular Weight | 455.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Voriconazole Impurity 88.
Voriconazole Impurity 88 (CAS CATO-C4X-136688) is a certified pharmaceutical impurity reference standard with the molecular formula C19H21ClF3N5OSi and a molecular weight of 455.94 g/mol.
Based on its molecular formula C19H21ClF3N5OSi, Voriconazole Impurity 88 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 455.94 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Voriconazole Impurity 88 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H21ClF3N5OSi |
| Molecular Weight | 455.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Voriconazole Standards
- Voriconazole Impurity 64 (CAS CATO-C4X-136664)
- Voriconazole Impurity 81 (CAS 1307315-04-3)
- Voriconazole Impurity 73 (CAS CATO-C4X-136673)
- Voriconazole Impurity 75 (CAS 321588-94-7)
- Voriconazole Impurity 5 (CAS 137234-75-4)
- Voriconazole Impurity 15 (CAS 137234-76-5)
- Voriconazole Impurity 17（Mixture of Diastereoisomer） (CAS 188416-35-5)
- Voriconazole Impurity 58 (CAS CATO-C4X-136658)
Recommended Standards
- 2-(5-((3-(4-Chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid (CAS 1009770-18-6)
- Apafant (CAS 105219-56-5)
- Montelukast 3-Oxo Benzoate (CAS 149968-11-6)
- (2Z)-3-{4-[(2H-1,3-benzodioxol-5-yl)methyl]piperazin-1-yl}-2-[(Z)-4-chlorobenzoyl]-3-(methylsulfanyl)prop-2-enenitrile (CAS 866009-17-8)
- Trazodone EP Impurity B (CAS 62337-66-0)
- Empagliflozin Impurity 101 (CAS CATO-C4X-1065101)
- Calcitriol impurity 01 (CAS 2239312-26-4)
- 4-chlorothiophen-3-amine hydrochloride (CAS 2002442-00-2)
- (3-Amino-4-ethylphenyl)methanol (CAS 5129-22-6)
- 2-(4-Chlorophenoxy)-1-(3-methylpiperazin-1-yl)ethan-1-one (CAS 1240564-90-2)
- 6-Bromo-3-iodo-1<I>H</I>-pyrazolo[4,3-<I>b</I>]pyridine (CAS 1305208-17-6)
- 1-(3-Fluoro-4-methoxyphenyl)cyclopentanamine (CAS 1344251-03-1)
- 1-[(oxan-4-yl)carbonyl]piperazine hydrochloride (CAS 1311317-59-5)
- Semaglutide impurity 46 (CAS CATO-C4X-222646)
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