Daptomycin Impurity B1-I CAS CATO-C4X-137824
| CAS No. | CATO-C4X-137824 |
| Molecular Formula | C44H66N10O15 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Daptomycin Impurity B1-I.
As a process- or degradation-related impurity, Daptomycin Impurity B1-I (CAS CATO-C4X-137824, C44H66N10O15•(C2HF3O2)) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Daptomycin Impurity B1-I (C44H66N10O15•(C2HF3O2)) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 17.0, corresponding to approximately 17 ring(s) or double-bond equivalent(s). With a molecular weight of 1089.09 g/mol, it falls into the high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C44H66N10O15 • (C2HF3O2) |
| Molecular Weight | 1089.09 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 10 |
Related Daptomycin Standards
- Daptomycin (CAS 103060-53-3)
- Daptomycin Impurity 2 (CAS 121869-35-0)
- Daptomycin Beta-Isomer (CAS 123180-72-3)
- Daptomycin-d5 (CAS 1356579-56-0)
- Daptomycin Impurity 55 (CAS 88399-21-7)
- Daptomycin Impurity 3 (CAS 883991-21-7)
- Daptomycin Impurity 10 (CAS CATO-C4X-137810)
- Daptomycin Impurity 11 (CAS CATO-C4X-137811)
Recommended Standards
- Ilaprazole Impurity 97 (CAS CATO-C4X-113097)
- Pemetrexed Impurity 33 (CAS 193265-47-3)
- Celecoxib Impurity 65 (CAS CATO-C4X-104365)
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- 2,5-Dibromo-4-(4-methoxyphenoxy)pyrimidine (CAS 1298101-41-3)
- Ethyl 3-(3-isopropylphenyl)-3-oxopropanoate (CAS 1260842-79-2)
- 1-(4-Fluorophenyl)-N-methyl-3-(methylthio)propan-2-amine (CAS 1247680-54-1)
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- [R-(R*,R*)]-5-[1-Hydroxy-2-[(1-methyl-3-phenylpropyl)(phenylmethyl)amino]ethyl]-2-(phenylmethoxy)benzamide (CAS 75615-55-3)
- Liraglutide (CAS 204656-20-2)
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