N-Desmethyl-N-Nitroso Venlafaxine EP Impurity F (Mixture of Isomers) CAS CATO-C4X-143449
| CAS No. | CATO-C4X-143449 |
| Molecular Formula | C16H22N2O2 |
| Molecular Weight | 274.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, N-Desmethyl-N-Nitroso Venlafaxine EP Impurity F (Mixture of Isomers) (CAS CATO-C4X-143449, C16H22N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of N-Desmethyl-N-Nitroso Venlafaxine EP Impurity F (Mixture of Isomers) (C16H22N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H22N2O2 |
| Molecular Weight | 274.36 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related N Standards
- N'-Desmethyl Amonafide-d5 (CAS 1215400-25-1)
- Desmethyl Gabazine (CAS 835870-49-0)
- N-Desmethyl Diazepam -D5 (CAS 65891-80-7)
- 3-Desmethyl Trimethoprim (CAS 27653-69-6)
- N-Desmethyl Asenapine HCl (CAS 128915-56-0)
- N-Desmethyl Mepyramine (CAS 104499-47-0)
- O-Desmethyl Pyrilamine (CAS 57830-29-2)
- N-Desmethyl cis-Terbinafine (CAS 114311-72-7)
Recommended Standards
- Aspirin impurity 31 (CAS CATO-C4X-140831)
- Paliperidone Impurity 166 (CAS CATO-C4X-1724166)
- Famotidine EP Impurity J (CAS 76824-14-1)
- Zidovudine EP Impurity K (CAS 596-31-6)
- Finerenone Impurity 17 (CAS CATO-C4X-288017)
- Valaciclovir EP Impurity D(hydrochloride) (CAS 1346617-49-9)
- Ceftazidime Impurity 59 (CAS CATO-C4X-121259)
- Benzil antimonoxine (CAS 14090-77-8)
- 3-Methyl Methcathinone Hydrochloride (CAS 1246816-62-5)
- 2-(Azepan-1-yl)pyrimidine-5-carbaldehyde (CAS 1339348-75-2)
- 2-Chloro-5h,7h,8h-thiopyrano[4,3-b]pyridine-3-carbonitrile (CAS 1251214-91-1)
- 4-(Propane-1-sulfonyl)aniline (CAS 86810-78-8)
- 2-Amino-5-bromo-3-chlorophenol (CAS 1426320-93-5)
- Hexapeptide-9 (CAS 885024-94-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com