Naloxone Impurity 22 CAS CATO-C4X-149322
| CAS No. | CATO-C4X-149322 |
| Molecular Formula | C20H23NO5 |
| Molecular Weight | 357.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 357.40 g/mol gives Naloxone Impurity 22 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Naloxone Impurity 22 (CAS CATO-C4X-149322) is a certified pharmaceutical impurity reference standard with the molecular formula C20H23NO5 and a molecular weight of 357.40 g/mol.
Naloxone Impurity 22 (C20H23NO5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Naloxone Impurity 22 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H23NO5 |
| Molecular Weight | 357.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Naloxone Standards
- Naloxone Impurity 21 (CAS CATO-C4X-149321)
- Naloxone Impurity 10 (CAS CATO-C4X-149310)
- Naloxone Impurity 11 (CAS CATO-C4X-149311)
- Naloxone Impurity 19 (CAS CATO-C4X-149319)
- Naloxone Hydrochloride EP Impurity B (CAS 1352085-46-1)
- Naloxone-d5 3-Methyl Ether (1.0mg/ml in Acetonitrile) (CAS 1261082-21-6)
- Naloxone-d5 HCl (CAS 1426174-78-8)
- Naloxone Impurity 17 (CAS CATO-C4X-149317)
Recommended Standards
- Naltrexone EP Impurity G (CAS CATO-C4X-14757)
- Ketorolac impurity 64 (CAS 141031-78-9)
- Naltrexone Impurity 61 (CAS CATO-C4X-147561)
- Nicergoline Impurity 31 (CAS CATO-C4X-208531)
- Ozanimod Impurity 30 (CAS CATO-C4X-29030)
- m-Phenylenediamine Impurity 5 (CAS CATO-C4X-34285)
- Difelikefalin Impurity 103 (CAS CATO-C4X-3041103)
- 1-tert-butoxycarbonylazepane-3-carboxylic acid (CAS 1252867-16-5)
- Trans-3-(4-methoxyphenyl)-4-methyl-5-phenyl-4,5-dihydroisoxazole (CAS 61191-48-8)
- 2-{[1-(4-Methylphenyl)-1H-pyrazol-4-yl]carbonyl}phenyl 2-furoate (CAS 955963-47-0)
- 2-(Benzyloxy)acetamide (CAS 5774-77-6)
- 4-[(3,4-difluorophenyl)methylidene]piperidine hydrochloride (CAS 1803583-97-2)
- 6-chloro-[1,2,4]triazolo[1,5-a]pyrimidine-2-carbaldehyde (CAS 749929-27-9)
- Tirzepatide Impurity 49 (CAS CATO-C4X-324049)
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