Norepinephrine Impurity 12 CAS CATO-C4X-151412
| CAS No. | CATO-C4X-151412 |
| Molecular Formula | C10H8Cl2O4 |
| Molecular Weight | 263.07 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Norepinephrine Impurity 12 (CAS CATO-C4X-151412) is a certified pharmaceutical impurity reference standard with the molecular formula C10H8Cl2O4 and a molecular weight of 263.07 g/mol.
Norepinephrine Impurity 12 (C10H8Cl2O4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H8Cl2O4 |
| Molecular Weight | 263.07 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Norepinephrine Standards
- Norepinephrine Impurity 132 (CAS CATO-C4X-1514132)
- Norepinephrine Impurity 14 (CAS 2948-15-4)
- Norepinephrine impurity 143 (CAS 2469755-95-9)
- Norepinephrine Impurity 97 (CAS CATO-C4X-151497)
- Norepinephrine Impurity 98 (CAS CATO-C4X-151498)
- Norepinephrine Impurity 64 (CAS CATO-C4X-151464)
- Norepinephrine Impurity 50 (CAS 100622-09-1)
- Norepinephrine Impurity 93 (CAS CATO-C4X-151493)
Recommended Standards
- (E)-1-bromanyl-1,1,2,2-tetrakis(fluoranyl)oct-3-ene (E)-1-bromo-1,1,2,2-tetrafluoro-3-octene 74793-72-9 A838230 (CAS 74793-72-9)
- 2-Fluoro-5-(trifluoromethyl)benzyl bromide 2-fluoro-5-trifluoromethylbenzyl bromide 2-fluoro-5-(trifluoromethylbenzyl) bromide 2-fluoro-5-(trifluoromethyl)benzylbromide 220239-69-0 (CAS 220239-69-0)
- 213203-65-7 3 - Fluoro - 4 - (trifluoromethyl)benzyl bromide 4-(bromomethyl)-2-fluoro-1-(trifluoromethyl)benzene 4-Bromomethyl-2-fluoro-1-trifluoromethyl-benzene benzene, 4-(bromomethyl)-2-fluoro-1-(trifluoromethyl)- (CAS 213203-65-7)
- Labetalol Impurity 61 (CAS CATO-C4X-246661)
- Amikacin Impurity 17 (CAS 1793053-92-5)
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- Cefotiam Impurity 45 (CAS CATO-C4X-120445)
- 1-Butyl-1h-1,2,3-triazol-4-amine (CAS 1528114-01-3)
- 4-Chloro-1,5-dimethyl-3-(trifluoromethyl)-1H-pyrazole (CAS 128694-69-9)
- 1-(3-(4-Chlorobenzoyl)piperidin-1-yl)-2,2,2-trifluoroethan-1-one (CAS 1794736-22-3)
- 3-chloro-2-nitrothiophene (CAS 33786-78-6)
- 1312716-26-9 C34H38N2O10 Scutebarbatine X W1398 (CAS 1312716-26-9)
- 5,5,5-Trifluoropentanenitrile (CAS 89866-61-5)
- Semaglutide (CAS 910463-68-2（free base）)
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