Norepinephrine impurity 146 CAS CATO-C4X-1514146
| CAS No. | CATO-C4X-1514146 |
| Molecular Formula | C16H19NO6 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Norepinephrine impurity 146 (CAS CATO-C4X-1514146, C16H19NO6C2HF3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C16H19NO6C2HF3O2, Norepinephrine impurity 146 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 435.35 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Norepinephrine impurity 146 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H19NO6 C2HF3O2 |
| Molecular Weight | 435.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Norepinephrine Standards
- Norepinephrine Impurity 50 (CAS 100622-09-1)
- Norepinephrine Impurity 103 (CAS 102743-86-2)
- Norepinephrine EP Impurity F (CAS 103-49-1)
- Norepinephrine Impurity 107 (CAS 112346-92-6)
- Norepinephrine Impurity 28 (CAS 117883-03-1)
- Norepinephrine Impurity 22 (CAS 1197-09-7)
- Norepinephrine Impurity 36 (CAS 121-28-8)
- Norepinephrine Impurity 161 (CAS 1215-29-8（free acid）)
Recommended Standards
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- Lacidipine Impurity 8 (CAS CATO-C4X-16718)
- H-Arg-Tyr-NH2 . 2 HCl (G-4095.0250) (CAS 128245-88-5)
- 1-(2-Fluoroethyl)-N-(furan-2-ylmethyl)-4-methyl-1H-pyrazol-3-amine hydrochloride (CAS 1856095-12-9)
- 3-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)amino)propane-1,2-diol (CAS 1393845-79-8)
- 6,8-Dichloro-3-(4-methylbenzyl)quinazolin-4(3H)-one (CAS 302913-35-5)
- Progesterone Impurity 42 (CAS 1173998-80-5)
- Landiolol Impurity 96 (CAS CATO-C4X-262196)
- Semaglutide Impurity 160 (x TFA Salt) (CAS CATO-C4X-2226160)
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