Aceclofenac Impurity 12 CAS CATO-C4X-153112
| CAS No. | CATO-C4X-153112 |
| Molecular Formula | C18H19Cl2NO3 |
| Molecular Weight | 368.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Aceclofenac Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Aceclofenac Impurity 12 (CAS CATO-C4X-153112), a pharmacopoeial impurity reference standard (molecular formula C18H19Cl2NO3, MW 368.25 g/mol) used for the identification and quantification of trace impurities in APIs.
Aceclofenac Impurity 12 (C18H19Cl2NO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H19Cl2NO3 |
| Molecular Weight | 368.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Aceclofenac Standards
- Aceclofenac Impurity 17 (CAS CATO-C4X-153117)
- Aceclofenac Methyl Ester (Aceclofenac EP Impurity D) (CAS 139272-66-5)
- Aceclofenac 13C2 D4 (CAS 1795019-63-4)
- Aceclofenac Ethyl (EsterAceclofenac EP Impurity E) (CAS 139272-67-6)
- Aceclofenac (CAS 89796-99-6)
- Aceclofenac Impurity 11 (CAS 2517857-21-3)
- Aceclofenac tert-Butyl Ester (CAS 139272-68-7)
- Aceclofenac EP Impurity G (CAS 1215709-75-3)
Recommended Standards
- 5-bromo-1-tosyl-1,5,6,7-tetrahydro-4H-indol-4-one (CAS 76989-06-5)
- N-[2-(4-Bromobenzenesulfonyl)ethyl]benzamide (CAS 338955-76-3)
- Perfluorophenyl 1-benzyl-1H-imidazole-4-carboxylate (CAS 1015856-09-3)
- N-(4-(2-bromoacetyl)phenyl)-4-methylbenzenesulfonamide (CAS 5317-95-3)
- Tetrabenazine Impurity 60 (CAS 2608769-99-7)
- Nafamostat impurity 71 (CAS CATO-C4X-133271)
- Alprostadil EP Impurity G (CAS 363-24-6)
- 4-Bromo-2-(pyrrolidin-1-ylmethyl)-1H-pyrrole (CAS 62426-06-6)
- (S)-(Pyrrolidin-3-yloxy)-acetic acid methyl ester hydrochloride (CAS 1414960-56-7)
- Fosdevirine-API (CAS 1018450-26-4)
- 2-[2-(1,3-thiazol-2-yl)ethyl]-2,3-dihydro-1H-isoindole-1,3-dione hydrobromide (CAS 1803587-28-1)
- Avibactam impurity 98 (CAS CATO-C4X-134898)
- 2,2'-Bis(4,5-dimethylimidazole) 4,4',5,5'-tetramethyl-1H,1'H-2,2'-biimidazole 69286-06-2 (CAS 69286-06-2)
- Semaglutide impurity 249 (CAS CATO-C4X-2226249)
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