Oxymetazoline Impurity 12 CAS CATO-C4X-172312
| CAS No. | CATO-C4X-172312 |
| Molecular Formula | C16H24N2O2 |
| Molecular Weight | 276.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Oxymetazoline Impurity 12 (CAS CATO-C4X-172312, C16H24N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Oxymetazoline Impurity 12 (C16H24N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Oxymetazoline Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H24N2O2 |
| Molecular Weight | 276.37 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | ＞90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related Oxymetazoline Standards
- Oxymetazoline Impurity 10 (CAS CATO-C4X-172310)
- Oxymetazoline Impurity 16 (CAS CATO-C4X-172316)
- Oxymetazoline Impurity 17 (CAS 756534-85-7)
- Oxymetazoline EP Impurity A (CAS 1391194-44-7)
- Oxymetazoline-d4 (imidazoline-d4) (CAS 1262053-60-0)
- Oxymetazoline impurity 8 (CAS CATO-C4X-17238)
- Oxymetazoline impurity 20 (CAS CATO-C4X-172320)
- Oxymetazoline impurity 21 (CAS CATO-C4X-172321)
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