Rapamycin Dehydration Impurity CAS CATO-C4X-174627
| CAS No. | CATO-C4X-174627 |
| Molecular Formula | C51H79NO13 |
| Molecular Weight | 914.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Rapamycin Dehydration Impurity.
As a process- or degradation-related impurity, Rapamycin Dehydration Impurity (CAS CATO-C4X-174627, C51H79NO13) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Rapamycin Dehydration Impurity (C51H79NO13) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Rapamycin Dehydration Impurity meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C51H79NO13 |
| Molecular Weight | 914.17 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Rapamycin Standards
- Rapamycin Impurity 12 (CAS 150821-39-9)
- Rapamycin Impurity 19 (CAS 144293-63-0)
- Rapamycin Impurity 21 (CAS 151945-42-5)
- Rapamycin Impurity 24 (CAS CATO-C4X-174624)
- Rapamycin Impurity 25 (CAS 151945-42-5 (racemic))
- Rapamycin Impurity 29 (CAS CATO-C4X-174629)
- Rapamycin Impurity 31 (CAS CATO-C4X-174631)
- Rapamycin Aldehyde Degrades Impurity (CAS CATO-C4X-174628)
Recommended Standards
- Seco Rapamycin (CAS 147438-27-5)
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