Nintedanib Impurity 178 CAS CATO-C4X-1814178
| CAS No. | CATO-C4X-1814178 |
| Molecular Formula | C47H42N6O7 |
| Molecular Weight | 802.87 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Nintedanib Impurity 178 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Nintedanib Impurity 178 (CAS CATO-C4X-1814178), a pharmacopoeial impurity reference standard (molecular formula C47H42N6O7, MW 802.87 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C47H42N6O7, Nintedanib Impurity 178 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 802.87 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nintedanib Impurity 178 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C47H42N6O7 |
| Molecular Weight | 802.87 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 30.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 6 |
Related Nintedanib Standards
- Nintedanib Impurity N6 (CAS CATO-C4X-12666)
- Nintedanib Demethyl-O-glucuronic Acid-d3 (CAS CATO-C4X-1814123)
- Nintedanib Demethyl-O-Glucuronide (CAS 1352789-50-4)
- Nintedanib Impurity 117 (CAS CATO-C4X-1814117)
- Nintedanib Impurity 2 (CAS 2410284-90-9)
- Nintedanib Impurity 27 (CAS CATO-C4X-181427)
- Nintedanib Impurity 106 (CAS CATO-C4X-1814106)
- Nintedanib Impurity 171 (CAS CATO-C4X-1814171)
Recommended Standards
- (1-((2R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl acetate (CAS 148380-57-8)
- Oxacillin Impurity 25 (CAS CATO-C4X-232125)
- Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP (CAS 253863-34-2)
- Oxacillin Impurity 31 (CAS CATO-C4X-232131)
- Toceranib impurity 2 (CAS CATO-C4X-25852)
- Irinotecan EP Impurity A (CAS 103816-16-6)
- Salbutamol Impurity 139 HCl (CAS CATO-C4X-1176139)
- N-(3-Amino-2-methylphenyl)-2-(dimethylamino)acetamide (CAS 946782-98-5)
- 6-(3,5-Dimethyl-1H-pyrazol-1-yl)-N-(p-tolyl)pyrimidin-4-amine (CAS 301328-20-1)
- 5-(4-Methoxyphenyl)-4-(prop-2-en-1-yl)-4h-1,2,4-triazole-3-thiol (CAS 88614-18-0)
- Dimethyl (Hydroxymethyl)phosphonate (CAS 24630-67-9)
- Etrasimod Impurity 38 (CAS 2863533-31-5)
- Cephalexin Impurity 12 (CAS 65870-52-2)
- Liraglutide Impurity 10 TFA Salt (CAS CATO-C4X-199210)
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